Gene
pdgfab
- ID
- ZDB-GENE-060929-124
- Name
- platelet-derived growth factor alpha polypeptide b
- Symbol
- pdgfab Nomenclature History
- Previous Names
-
- wu:fc32c12
- zgc:153249
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable platelet-derived growth factor receptor binding activity. Involved in angiogenesis. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in endoderm; mouth; pharyngeal arch; pharyngeal endoderm; and pharyngeal pouch. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Owen et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pdgfab | (3) | |
| CRISPR2-pdgfab | Zebrafish Nomenclature Committee | |
| MO1-pdgfab | N/A | Mao et al., 2019 |
| MO2-pdgfab | N/A | Owen et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site | Platelet-derived growth factor, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BAV6 | InterPro | 207 | ||||
| UniProtKB:Q08CD2 | InterPro | 230 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
pdgfab-202
(1)
|
Ensembl | 876 nt | ||
| mRNA |
pdgfab-201
(1)
|
Ensembl | 2,286 nt | ||
| mRNA |
pdgfab-204
(1)
|
Ensembl | 1,181 nt | ||
| ncRNA |
pdgfab-004
(1)
|
Ensembl | 579 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-8C17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-103A8 | ZFIN Curated Data | |
| Encodes | EST | fc32c12 | ||
| Encodes | cDNA | MGC:153249 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001076757 (1) | 1888 nt | ||
| Genomic | GenBank:BX005166 (1) | 178013 nt | ||
| Polypeptide | UniProtKB:Q08CD2 (1) | 230 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | PDGFA | 7 | Amino acid sequence comparison (1) |
- Ye, W., Shi, M., Cheng, Y., Liu, Y., Ren, K., Fang, Y., Younas, W., Zhang, W., Wang, Y., Xia, X.Q. (2025) Integrated single-cell transcriptome and comparative genome analysis reveal origin of intermuscular bones in zebrafish. International journal of biological macromolecules. :142397142397
- Lee, J., Goeckel, M.E., Levitas, A., Colijn, S., Shin, J., Hindes, A., Mun, G., Burton, Z., Chintalapati, B., Yin, Y., Abello, J., Solnica-Krezel, L., Stratman, A. (2024) CXCR3-CXCL11 Signaling Restricts Angiogenesis and Promotes Pericyte Recruitment. Arteriosclerosis, Thrombosis, and Vascular Biology. 44(12):2577-2595
- Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
- Singh Angom, R., Wang, Y., Wang, E., Dutta, S., Mukhopadhyay, D. (2023) Conditional, Tissue-Specific CRISPR/Cas9 Vector System in Zebrafish Reveals the Role of Nrp1b in Heart Regeneration. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(10):1921-1934
- Owen, N., Toms, M., Young, R.M., Eintracht, J., Sarkar, H., Brooks, B.P., Moosajee, M., Genomics England Research Consortium (2022) Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Genetics in medicine : official journal of the American College of Medical Genetics. 24(5):1073-1084
- Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:
- Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52
- Tsata, V., Möllmert, S., Schweitzer, C., Kolb, J., Möckel, C., Böhm, B., Rosso, G., Lange, C., Lesche, M., Hammer, J., Kesavan, G., Beis, D., Guck, J., Brand, M., Wehner, D. (2020) A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Developmental Cell. 56(4):509-524.e9
- Lowe, V., Wisniewski, L., Sayers, J., Evans, I., Frankel, P., Mercader-Huber, N., Zachary, I.C., Pellet-Many, C. (2019) Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart. Development (Cambridge, England). 146(13):
- Mao, A., Zhang, M., Liu, J., Cao, Y., Wang, Q. (2019) PDGF signaling from pharyngeal pouches promotes arch artery morphogenesis. Journal of genetics and genomics = Yi chuan xue bao. 46(12):551-559
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