Gene

scn12aa

ID
ZDB-GENE-060908-2
Name
sodium channel, voltage gated, type XII, alpha a
Symbol
scn12aa Nomenclature History
Previous Names
  • scn5Laa (1)
  • zscn6 (1)
  • zmp:0000001002
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable voltage-gated sodium channel activity. Acts upstream of or within heart looping and regulation of heart contraction. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in nervous system and pericardial region.
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Chopra et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa12084Allele with one point mutationUnknownPremature StopENU
sa12942Allele with one point mutationUnknownPremature StopENU
sa15768Allele with one point mutationUnknownPremature StopENU
sa19899Allele with one point mutationUnknownPremature StopENU
sa33047Allele with one point mutationUnknownUnknownENU
sa39947Allele with one point mutationUnknownUnknownENU
1 - 6 of 6
Show
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-scn12aaN/A (3)
MO2-scn12aaN/AChopra et al., 2010
MO3-scn12aaN/AChiang et al., 2023
1 - 3 of 3
Show
Human Disease
Associated With scn12aa Human Ortholog
No data available
Associated With scn12aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR005821 Ion transport domain
Domain IPR010526 Sodium ion transport-associated domain
Domain IPR024583 Voltage-gated Na+ ion channel, cytoplasmic domain
Domain IPR044564 Voltage-gated sodium channel alpha subunit, inactivation gate
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Additional Resources Length Ion transport domain IQ motif, EF-hand binding site Sodium ion transport-associated domain Voltage-dependent channel domain superfamily Voltage-gated cation channel calcium and sodium Voltage-gated Na+ ion channel, cytoplasmic domain Voltage gated sodium channel, alpha subunit Voltage-gated sodium channel alpha subunit, inactivation gate
UniProtKB:Q20JQ5 InterPro 1932
UniProtKB:A0A8M3B7Z1 InterPro 1940
UniProtKB:A0AB32T6B6 InterPro 1932
1 - 3 of 3
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA scn12aa-201 (1) Ensembl 5,799 nt
mRNA scn12aa-202 (1) Ensembl 267 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-137C4ZFIN Curated Data
1 - 1 of 1
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations
1 - 10 of 19
Show