ZFIN is now using GRCz12tu for Genomic Data
Gene
kctd13
- ID
- ZDB-GENE-060825-162
- Name
- potassium channel tetramerization domain containing 13
- Symbol
- kctd13 Nomenclature History
- Previous Names
-
- zgc:153421
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to contribute to ubiquitin-protein transferase activity. Involved in negative regulation of Rho protein signal transduction and neural precursor cell proliferation. Acts upstream of or within central nervous system development; cranial skeletal system development; and positive regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in brain; forebrain; hindbrain; midbrain; and retina. Orthologous to human KCTD13 (potassium channel tetramerization domain containing 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a160 | Allele with one delins | Unknown | Unknown | CRISPR | |
| a290 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| la028858Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nv966 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| sa13226 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16855 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa26011 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33114 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33115 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| wi700 | Allele with one deletion | Unknown | Unknown | TALEN |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1-3 | Potassium channel tetramerisation-type BTB domain | SKP1/BTB/POZ domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A9ULR9 | InterPro | 330 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kctd13-201
(1)
|
Ensembl | 2,087 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-282H22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153421 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173497 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173498 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077151 (1) | 2098 nt | ||
| Genomic | GenBank:AL929124 (1) | 165243 nt | ||
| Polypeptide | UniProtKB:A9ULR9 (1) | 330 aa |
- Bai, C., Zheng, Y., Tian, L., Lin, J., Song, Y., Huang, C., Dong, Q., Chen, J. (2023) Structure-based developmental toxicity and ASD-phenotypes of bisphenol A analogues in embryonic zebrafish. Ecotoxicology and environmental safety. 253:114643114643
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Qiu, Y., Arbogast, T., Lorenzo, S.M., Li, H., Tang, S.C., Richardson, E., Hong, O., Cho, S., Shanta, O., Pang, T., Corsello, C., Deutsch, C.K., Chevalier, C., Davis, E.E., Iakoucheva, L.M., Herault, Y., Katsanis, N., Messer, K., Sebat, J. (2019) Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development. Cell Reports. 28:3320-3328.e4
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Kasap, M., Rajani, V., Rajani, J., Dwyer, D.S. (2018) Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability. Schizophrenia research. 202:120-128
- Carter, B.S., Cortés-Campos, C., Chen, X., McCammon, J.M., Sive, H.L. (2017) Validation of Protein Knockout in Mutant Zebrafish Lines Using In Vitro Translation Assays. Zebrafish. 14(1):73-76
- Escamilla, C.O., Filonova, I., Walker, A.K., Xuan, Z.X., Holehonnur, R., Espinosa, F., Liu, S., Thyme, S.B., López-García, I.A., Mendoza, D.B., Usui, N., Ellegood, J., Eisch, A.J., Konopka, G., Lerch, J.P., Schier, A.F., Speed, H.E., Powell, C.M. (2017) Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 551(7679):227-231
- McCammon, J.M., Blaker-Lee, A., Chen, X., Sive, H. (2017) The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human molecular genetics. 26:3699-3712
- Wang, Y., Zhong, H., Wang, C., Gao, D., Zhou, Y., Zuo, Z. (2016) Maternal exposure to the water soluble fraction of crude oil, lead and their mixture induces autism-like behavioral deficits in zebrafish (Danio rerio) larvae. Ecotoxicology and environmental safety. 134P1:23-30
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