Gene
wnt2bb
- ID
- ZDB-GENE-060824-6
- Name
- wingless-type MMTV integration site family, member 2Bb
- Symbol
- wnt2bb Nomenclature History
- Previous Names
-
- prometheus
- prt
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Involved in liver development. Acts upstream of or within several processes, including angiogenesis; hepaticobiliary system development; and swim bladder development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; heart; mesoderm; nervous system; and primordial vasculature. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| s403 | Allele with one point mutation | Unknown | Missense | ENU | |
| s404 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| s416 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34423 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34424 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| wnt2bb_unspecified | Unspecified Allele | Unknown | Unknown | not specified |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diarrhea 9 | 618168 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wnt | Wnt-2 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q1L130 | InterPro | 396 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
wnt2bb-201
(1)
|
Ensembl | 1,413 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:dnwnt2bb-2A-GFP,cryaa:mCherry) |
| 1 | Peng et al., 2020 | ||
| Tg(hsp70l:mCherry,wnt2bb) |
|
| 1 | (2) | |
| Tg(hsp70l:mCherry,wnt2bb,cryaa:ECFP) |
| 1 | (3) | ||
| Tg(hsp70l:wnt2bb-2A-mCherry,cryaa:GFP) |
| 1 | Peng et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-67N5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194365 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194374 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044344 (1) | 1413 nt | ||
| Genomic | GenBank:BX072558 (1) | 171364 nt | ||
| Polypeptide | UniProtKB:Q1L130 (1) | 396 aa |
- Shi, W., Yi, X., Ruan, H., Wang, D., Wu, D., Jiang, P., Luo, L., Ma, X., Jiang, F., Li, C., Wu, W., Luo, L., Li, L., Wang, G., Qiu, J., Huang, H. (2025) An animal model recapitulates human hepatic diseases associated with GATA6 mutations. Proceedings of the National Academy of Sciences of the United States of America. 122:e2317801121e2317801121
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Guo, X., Yang, L., Wang, Y., Yuan, M., Zhang, W., He, X., Wang, Q. (2024) Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. :
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
- Yang, S., Zhang, X., Li, X., Yin, X., Teng, L., Ji, G., Li, H. (2022) Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. International Journal of Molecular Sciences. 23(14):
- Yang, Y., Li, Y., Fu, J., Li, Y., Li, S., Ni, R., Yang, Q., Luo, L. (2022) Intestinal precursors avoid being misinduced to liver cells by activating Cdx-Wnt inhibition cascade. Proceedings of the National Academy of Sciences of the United States of America. 119:e2205110119
- Abu Nahia, K., Migdał, M., Quinn, T.A., Poon, K.L., Łapiński, M., Sulej, A., Liu, J., Mondal, S.S., Pawlak, M., Bugajski, Ł., Piwocka, K., Brand, T., Kohl, P., Korzh, V., Winata, C. (2021) Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region. Cellular and molecular life sciences : CMLS. 78(19-20):6669-6687
- Bian, W.P., Pu, S.Y., Xie, S.L., Wang, C., Deng, S., Strauss, P.R., Pei, D.S. (2021) Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish. Cell death discovery. 7:250
- Lin, Z., Luo, M., Zhou, B., Liu, Y., Sun, H. (2021) CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish. Immunology Letters. 234:47-53
- den Broeder, M.J., Ballangby, J., Kamminga, L.M., Aleström, P., Legler, J., Lindeman, L.C., Kamstra, J.H. (2020) Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish. Epigenetics & chromatin. 13:5
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