Gene
her4.2
- ID
- ZDB-GENE-060815-1
- Name
- hairy-related 4, tandem duplicate 2
- Symbol
- her4.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within peripheral nervous system neuron axonogenesis. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; midbrain neural keel; neural plate; and neural tube.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb497 (27 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1023 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO2-her4 | N/A | (3) |
| MO3-her4 | N/A | Henry et al., 2002 |
| MO4-her4 | N/A | Gao et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Hairy and Enhancer of Split/HEY-related | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain |
|---|---|---|---|---|---|---|
| UniProtKB:B0V3D1 | InterPro | 152 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
her4.2-202
(1)
|
Ensembl | 1,694 nt | ||
| mRNA |
her4.2-203
(1)
|
Ensembl | 1,737 nt | ||
| mRNA |
her4.2-204
(1)
|
Ensembl | 1,799 nt | ||
| mRNA |
her4.2-205
(1)
|
Ensembl | 1,804 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-21G5 | ZFIN Curated Data | |
| Contains | SNP | rs3729486 | ZFIN Curated Data | |
| Encodes | EST | cb497 | Thisse et al., 2001 | |
| Encodes | EST | fe18g04 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001161409 (1) | 1694 nt | ||
| Genomic | GenBank:CU062502 (1) | 62011 nt | ||
| Polypeptide | UniProtKB:B0V3D1 (1) | 152 aa |
No data available
- Engel-Pizcueta, C., Hevia, C.F., Voltes, A., Livet, J., Pujades, C. (2024) Her9 controls the stemness properties of hindbrain boundary cells. Development (Cambridge, England). 152(1):
- Kuil, L.E., Kakiailatu, N.J.M., Windster, J.D., Bindels, E., Zink, J.T.M., van der Zee, G., Hofstra, R.M.W., Shepherd, I.T., Melotte, V., Alves, M.M. (2023) Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level. iScience. 26:107070107070
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
- Wang, M., Du, L., Lee, A.C., Li, Y., Qin, H., He, J. (2020) Different lineage contexts direct common pro-neural factors to specify distinct retinal cell subtypes. The Journal of cell biology. 219(9):
- Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J. (2020) Unifying Developmental Programs for Embryonic and Post-Embryonic Neurogenesis in the Zebrafish Retina. Development (Cambridge, England). 147(12):
- Albadri, S., Naso, F., Thauvin, M., Gauron, C., Parolin, C., Duroure, K., Vougny, J., Fiori, J., Boga, C., Vriz, S., Calonghi, N., Del Bene, F. (2019) Redox Signaling via Lipid Peroxidation Regulates Retinal Progenitor Cell Differentiation. Developmental Cell. 50(1):73-89.e6
- Huang, V., Butler, A.A., Lubin, F.D. (2019) Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Scientific Reports. 9:1379
- Yu, S., He, J. (2019) Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish. eLIFE. 8
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