Gene
myo1ha
- ID
- ZDB-GENE-060531-78
- Name
- myosin IHa
- Symbol
- myo1ha Nomenclature History
- Previous Names
-
- si:dkey-189p24.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within cranial skeletal system development. Predicted to be located in cell cortex; ruffle membrane; and stereocilium membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Is expressed in brain; mandibular arch skeleton; neuromast; otic sensory epithelium; and pharyngeal arch. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human MYO1H (myosin IH).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Sun et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction | 619482 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR010926 | Class I myosin tail homology domain |
| Domain | IPR036072 | Class I myosin, motor domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Class I myosin, motor domain | Class I myosin tail homology domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QEJ0 | InterPro | 1039 | ||||||
| UniProtKB:A0A8M3B9I7 | InterPro | 1059 | ||||||
| UniProtKB:A0AB32TU83 | InterPro | 1036 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo1ha-201
(1)
|
Ensembl | 2,973 nt | ||
| mRNA |
myo1ha-202
(1)
|
Ensembl | 3,083 nt |
Interactions and Pathways
No data available
Plasmids
No data available