Gene
pappab
- ID
- ZDB-GENE-060526-71
- Name
- pregnancy-associated plasma protein A, pappalysin 1b
- Symbol
- pappab Nomenclature History
- Previous Names
-
- si:ch211-196f15.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables peptidase activity. Acts upstream of or within chordate embryonic development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; muscle; nervous system; pleuroperitoneal region; and skeletal tissue. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PAPPA (pappalysin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kjaer-Sorensen et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000436 | Sushi/SCR/CCP domain |
| Domain | IPR000800 | Notch domain |
| Domain | IPR006558 | LamG-like jellyroll fold |
| Domain | IPR008754 | Peptidase M43, pregnancy-associated plasma-A |
| Family | IPR043543 | Pappalysin-1/2 |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR035976 | Sushi/SCR/CCP superfamily |
| Repeat | IPR011936 | Myxococcus cysteine-rich repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | LamG-like jellyroll fold | Metallopeptidase, catalytic domain superfamily | Myxococcus cysteine-rich repeat | Notch domain | Pappalysin-1/2 | Peptidase M43, pregnancy-associated plasma-A | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ASU7 | InterPro | 1633 | |||||||||
| UniProtKB:M1WXG8 | InterPro | 1624 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pappab-201
(1)
|
Ensembl | 5,091 nt | ||
| mRNA |
pappab-202
(1)
|
Ensembl | 599 nt | ||
| mRNA |
pappab-203
(1)
|
Ensembl | 4,821 nt |
Interactions and Pathways
No data available
Plasmids
No data available