Gene
f2r
- ID
- ZDB-GENE-060526-30
- Name
- coagulation factor II (thrombin) receptor
- Symbol
- f2r Nomenclature History
- Previous Names
-
- PAR1-5A (1)
- si:ch211-130m23.4
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables thrombin-activated receptor activity. Acts upstream of or within endothelial to hematopoietic transition; lymphatic endothelial cell differentiation; and negative regulation of hematopoietic stem cell differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic system; mesoderm; and pleuroperitoneal region. Orthologous to human F2R (coagulation factor II thrombin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-f2r | Lei et al., 2021 | |
| MO1-f2r | N/A | (3) |
| MO2-f2r | N/A | Yue et al., 2012 |
| MO3-f2r | N/A | Ellertsdottir et al., 2012 |
| MO4-f2r | N/A | Duan et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Protease-activated receptor | Thrombin receptor |
|---|---|---|---|---|---|---|
| UniProtKB:A2BIP6 | InterPro | 413 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(lyve1b:f2r-2A-mCherry) |
| 1 | Lei et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-130M23 | ZFIN Curated Data | |
| Contained in | BAC | CH211-157P10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114846 (1) | 1242 nt | ||
| Genomic | GenBank:BX950872 | 141660 nt | ||
| Polypeptide | UniProtKB:A2BIP6 (1) | 413 aa |
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Lei, D., Zhang, X., Rouf, M.A., Mahendra, Y., Wen, L., Li, Y., Zhang, X., Li, L., Wang, L., Zhang, T., Wang, G., Wang, Y. (2021) Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish. iScience. 24:103386
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Duan, J., Liang, S., Yu, Y., Li, Y., Wang, L., Wu, Z., Chen, Y., Miller, M.R., Sun, Z. (2018) Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos. Nanotoxicology. 12(5):470-484
- Chen, L., Zhu, B., Guo, Y., Xu, T., Lee, J.S., Qian, P.Y., Zhou, B. (2016) High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 214:324-333
- Duan, J., Yu, Y., Li, Y., Wang, Y., Sun, Z. (2016) Inflammatory response and blood hypercoagulable state induced by low level co-exposure with silica nanoparticles and benzo[a]pyrene in zebrafish (Danio rerio) embryos. Chemosphere. 151:152-162
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ellertsdottir, E., Berthold, P.R, Bouzaffour, M., Dufourcq, P., Trayer, V., Gauron, C., Vriz, S., Affolter, M., and Rampon, C. (2012) Developmental Role of Zebrafish Protease-Activated Receptor 1 (PAR1) in the Cardio-Vascular System. PLoS One. 7(7):e42131
- Yang, D., Liu, Q., Yang, M., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2012) RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. BMC Genomics. 13(1):319
- Yue, R., Li, H., Liu, H., Li, Y., Wei, B., Gao, G., Jin, Y., Liu, T., Wei, L., Du, J., and Pei, G. (2012) Thrombin Receptor Regulates Hematopoiesis and Endothelial-to-Hematopoietic Transition. Developmental Cell. 22(5):1092-1100
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