Gene
slc4a4a
- ID
- ZDB-GENE-060526-274
- Name
- solute carrier family 4 member 4a
- Symbol
- slc4a4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Predicted to act upstream of or within monoatomic anion transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including central nervous system; eye; intermediate mesoderm; optic cup; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sussman et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Proximal renal tubular acidosis-ocular anomaly syndrome | 604278 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011531 | Bicarbonate transporter-like, transmembrane domain |
| Domain | IPR013769 | Band 3 cytoplasmic domain |
| Family | IPR003020 | Bicarbonate transporter, eukaryotic |
| Family | IPR003024 | Sodium bicarbonate cotransporter |
| Homologous_superfamily | IPR016152 | Phosphotransferase/anion transporter |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 3 cytoplasmic domain | Bicarbonate transporter, eukaryotic | Bicarbonate transporter-like, transmembrane domain | Phosphotransferase/anion transporter | Sodium bicarbonate cotransporter |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q3ZMH2 | InterPro | 1082 | |||||
| UniProtKB:A0A2R8QD45 | InterPro | 1073 | |||||
| UniProtKB:A0A8M3ASQ6 | InterPro | 1146 | |||||
| UniProtKB:A0A8M3B2R8 | InterPro | 1114 | |||||
| UniProtKB:A0A8M3AZV9 | InterPro | 1105 | |||||
| UniProtKB:A0A8M9Q3P6 | InterPro | 1114 | |||||
| UniProtKB:A0AB32TPR4 | InterPro | 1089 | |||||
| UniProtKB:A0AB32TTV9 | InterPro | 1098 | |||||
| UniProtKB:A0AB32TVF5 | InterPro | 1130 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc4a4a-201
(1)
|
Ensembl | 6,227 nt | ||
| mRNA |
slc4a4a-202
(1)
|
Ensembl | 2,810 nt | ||
| mRNA |
slc4a4a-205
(1)
|
Ensembl | 6,323 nt | ||
| mRNA |
slc4a4a-206
(1)
|
Ensembl | 3,417 nt | ||
| ncRNA |
slc4a4a-002
(1)
|
Ensembl | 499 nt | ||
| ncRNA |
slc4a4a-003
(1)
|
Ensembl | 542 nt |
Interactions and Pathways
No data available
Plasmids
No data available