Gene
bmp10
- ID
- ZDB-GENE-060526-211
- Name
- bone morphogenetic protein 10
- Symbol
- bmp10 Nomenclature History
- Previous Names
-
- bmp10b (1)
- si:dkey-13n15.5
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within artery development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver and pericardial region. Used to study hereditary hemorrhagic telangiectasia. Orthologous to human BMP10 (bone morphogenetic protein 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
pt527 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
pt543 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | TALEN | |
sa7560 | Allele with one point mutation | Unknown | Missense | ENU | |
sa16377 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa20384 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa33575 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40400 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 7 of 7
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-bmp10 | Hu et al., 2024 | |
MO1-bmp10 | N/A | Laux et al., 2013 |
MO2-bmp10 | N/A | Laux et al., 2013 |
TALEN1-bmp10 | (3) |
1 - 4 of 4
Show
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
hereditary hemorrhagic telangiectasia | bmp10pt527/pt527; pt505Tg; twu34Tg | control | Capasso et al., 2019 |
1 - 1 of 1
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
Domain | IPR001111 | TGF-beta, propeptide |
Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
Family | IPR015615 | Transforming growth factor-beta-related |
Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
1 - 5 of 5
Domain Details Per Protein
Protein | Additional Resources | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
---|---|---|---|---|---|---|---|
UniProtKB:A2BGK2 | InterPro | 485 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-13N15 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195288 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001130600 (1) | 1529 nt | ||
Genomic | GenBank:BX470224 (1) | 244492 nt | ||
Polypeptide | UniProtKB:A2BGK2 (1) | 485 aa |
- Anzell, A.R., Kunz, A.B., Donovan, J.P., Tran, T.G., Lu, X., Young, S., Roman, B.L. (2024) Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. Angiogenesis. 27(3):501-522
- Hu, R., Li, G., Hu, P., Niu, H., Li, W., Jiang, S., Guan, G., Xu, Q., Liu, M., Chen, L. (2024) bmp10 maintains cardiac function by regulating iron homeostasis. Journal of genetics and genomics = Yi chuan xue bao. 51(12):1459-1473
- Auman, H.J., Fernandes, I.H., Berríos-Otero, C.A., Colombo, S., Yelon, D. (2023) Zebrafish smarcc1a mutants reveal requirements for BAF chromatin remodeling complexes in distinguishing the atrioventricular canal from the cardiac chambers. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):157-172
- Meng, Y., Zhong, K., Chen, S., Huang, Y., Wei, Y., Wu, J., Liu, J., Xu, Z., Guo, J., Liu, F., Lu, H. (2021) Cardiac toxicity assessment of pendimethalin in zebrafish embryos. Ecotoxicology and environmental safety. 222:112514
- Wang, W., Hu, Y.F., Pang, M., Chang, N., Yu, C., Li, Q., Xiong, J.W., Peng, Y., Zhang, R. (2021) BMP and Notch Signaling Pathways differentially regulate Cardiomyocyte Proliferation during Ventricle Regeneration. International journal of biological sciences. 17:2157-2166
- Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738
- Meng, Y., Zhong, K., Xiao, J., Huang, Y., Wei, Y., Tang, L., Chen, S., Wu, J., Ma, J., Cao, Z., Liao, X., Lu, H. (2020) Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish. Chemosphere. 255:126889
- Capasso, T.L., Li, B., Volek, H.J., Khalid, W., Rochon, E.R., Anbalagan, A., Herdman, C., Yost, H.J., Villanueva, F.S., Kim, K., Roman, B.L. (2019) BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance. Angiogenesis. 23(2):203-220
- Gálvez-Santisteban, M., Chen, D., Zhang, R., Serrano, R., Nguyen, C., Zhao, L., Nerb, L., Masutani, E.M., Vermot, J., Burns, C.G., Burns, C.E., Del Álamo, J.C., Chi, N.C. (2019) Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. eLIFE. 8:
- Gong, G., Kam, H., Tse, Y., Lee, S.M. (2019) Cardiotoxicity of forchlorfenuron (CPPU) in zebrafish (Danio rerio) and H9c2 cardiomyocytes. Chemosphere. 235:153-162
1 - 10 of 22
Show