Gene
tet3
- ID
- ZDB-GENE-060526-109
- Name
- tet methylcytosine dioxygenase 3
- Symbol
- tet3 Nomenclature History
- Previous Names
-
- si:ch211-220a11.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables DNA 5-methylcytosine dioxygenase activity. Involved in regulation of gene expression. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to lipopolysaccharide; and endothelial to hematopoietic transition. Predicted to be located in chromosome. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; eye; hematopoietic system; liver; and pleuroperitoneal region. Orthologous to human TET3 (tet methylcytosine dioxygenase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bogdanović et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| au60 | Allele with one delins | Exon 6 | Frameshift, Premature Stop | TALEN | |
| bjz1 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| ihb2020 | Allele with one insertion | Exon 2 | Unknown | TALEN | |
| ki118 | Allele with one deletion | Unknown | Unknown | not specified | |
| mk18 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| sa9686 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16660 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33552 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| waw203 | Allele with one deletion | Unknown | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tet3 | (2) | |
| CRISPR2-tet3 | (2) | |
| CRISPR3-tet3 | (2) | |
| CRISPR4-tet3 | (2) | |
| CRISPR5-tet3 | (2) | |
| CRISPR6-tet3 | (2) | |
| CRISPR7-tet3 | (2) | |
| CRISPR8-tet3 | (2) | |
| CRISPR9-tet3 | (2) | |
| CRISPR10-tet3 | Wang et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Beck-Fahrner syndrome | 618798 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 2OGFeDO JBP1/TET, oxygenase domain | Methylcytosine dioxygenase TET1/2/3 | Methylcytosine dioxygenase TET1-3, oxygenase domain | Zinc finger, CXXC-type |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q4R6 | InterPro | 2052 | ||||
| UniProtKB:A0A8M1P9L5 | InterPro | 1895 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-185J11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-220A11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327945 (1) | 10825 nt | ||
| Genomic | GenBank:CR388049 (2) | 201176 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q4R6 (1) | 2052 aa |
- Heilman, S.A., Schriever, H.C., Kostka, D., Koenig, K.M., Gross, J.M. (2025) tet2 and tet3 regulate cell fate specification and differentiation events during retinal development. Scientific Reports. 15:1040410404
- Jia, K., Cheng, B., Huang, L., Xu, J., Liu, F., Liao, X., Liao, K., Lu, H. (2025) Activation of prep expression by Tet2 promotes the proliferation of bipotential progenitor cells during liver regeneration. Development (Cambridge, England). :
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Avagyan, S., Henninger, J.E., Mannherz, W.P., Mistry, M., Yoon, J., Yang, S., Weber, M.C., Moore, J.L., Zon, L.I. (2021) Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science (New York, N.Y.). 374:768-772
- Banks, K.M., Lan, Y., Evans, T. (2021) Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA. Cell Reports. 34:108632
- Rajan, V., Collett, K., Woodside, R., Prykhozhij, S.V., Moksa, M., Carles, A., Wong, M., Liebman, M., Hirst, M., Berman, J.N. (2021) Stress hematopoiesis induces a proliferative advantage in TET2 deficiency. Leukemia. 36(3):809-820
- Ross, S.E., Hesselson, D., Bogdanovic, O. (2021) Developmental Accumulation of Gene Body and Transposon Non-CpG Methylation in the Zebrafish Brain. Frontiers in cell and developmental biology. 9:643603
- Wang, X., Ma, X., Wei, G., Ma, W., Zhang, Z., Chen, X., Gao, L., Liu, Z., Yuan, Y., Yi, L., Wang, J., Tokumoto, T., Huang, J., Chen, D., Zhang, J., Liu, J. (2021) The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish. Genomics, proteomics & bioinformatics. 19(1):48-63
- Bautista, N.M., Crespel, A., Crossley, J., Padilla, P., Burggren, W. (2020) Parental transgenerational epigenetic inheritance related to dietary crude oil exposure in Danio rerio. The Journal of experimental biology. 223(Pt 16):
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