Gene
ccr7
- ID
- ZDB-GENE-060522-2
- Name
- chemokine (C-C motif) receptor 7
- Symbol
- ccr7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables G protein-coupled receptor activity. Acts upstream of or within dorsal/ventral pattern formation and negative regulation of canonical Wnt signaling pathway. Predicted to be located in early endosome and plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in brain; gill; intestine; and kidney. Orthologous to human CCR7 (C-C motif chemokine receptor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Liu et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
stl7 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | TALEN |
1 - 1 of 1
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-ccr7 | N/A | Eckfeldt et al., 2005 |
MO2-ccr7 | N/A | (2) |
TALEN1-ccr7 | Malhotra et al., 2018 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
Family | IPR000355 | Chemokine receptor family |
Family | IPR001277 | CXC chemokine receptor 4/atypical chemokine receptor 2 |
Family | IPR050119 | C-C chemokine receptor type 1-9-like |
1 - 5 of 5
Domain Details Per Protein
Protein | Additional Resources | Length | C-C chemokine receptor type 1-9-like | Chemokine receptor family | CXC chemokine receptor 4/atypical chemokine receptor 2 | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
---|---|---|---|---|---|---|---|
UniProtKB:A5PLI3 | InterPro | 372 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-3D18 | ZFIN Curated Data | |
Encodes | cDNA | MGC:165629 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001098743 (1) | 1199 nt | ||
Genomic | GenBank:BX546447 (2) | 111358 nt | ||
Polypeptide | UniProtKB:A5PLI3 (1) | 372 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | CCR7 | 17 | Amino acid sequence comparison (3) |
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Ratnayake, D., Nguyen, P.D., Rossello, F.J., Wimmer, V.C., Tan, J.L., Galvis, L.A., Julier, Z., Wood, A.J., Boudier, T., Isiaku, A.I., Berger, S., Oorschot, V., Sonntag, C., Rogers, K.L., Marcelle, C., Lieschke, G.J., Martino, M.M., Bakkers, J., Currie, P.D. (2021) Macrophages provide a transient muscle stem cell niche via NAMPT secretion. Nature. 591(7849):281-287
- Shi, W., Shao, T., Li, J.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 203(9):2425-2442
- Malhotra, D., Shin, J., Solnica-Krezel, L., Raz, E. (2018) Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors. eLIFE. 7
- Blaser, B.W., Moore, J.L., Hagedorn, E.J., Li, B., Riquelme, R., Lichtig, A., Yang, S., Zhou, Y., Tamplin, O.J., Binder, V., Zon, L.I. (2017) CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. The Journal of experimental medicine. 214(4):1011
- Xue, Y., Lv, J., Zhang, C., Wang, L., Ma, D., Liu, F. (2017) The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b. Developmental Cell. 42(4):349-362.e4
- Mackay, E.W., Apschner, A., Schulte-Merker, S. (2015) Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI. Development (Cambridge, England). 142:1095-101
- Nomiyama, H., Osada, N., and Yoshie, O. (2013) Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history. Genes to cells : devoted to molecular & cellular mechanisms. 18(1):1-16
- Wu, S.Y., Shin, J., Sepich, D.S., and Solnica-Krezel, L. (2012) Chemokine GPCR Signaling Inhibits β-Catenin during Zebrafish Axis Formation. PLoS Biology. 10(10):e1001403
- Liu, Y., Chang, M.X., Wu, S.G., and Nie, P. (2009) Characterization of C-C chemokine receptor subfamily in teleost fish. Molecular immunology. 46(3):498-504
1 - 10 of 13
Show