Gene
smyd1b
- ID
- ZDB-GENE-060522-1
- Name
- SET and MYND domain containing 1b
- Symbol
- smyd1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables histone H3K4 methyltransferase activity and myosin binding activity. Acts upstream of or within heart contraction; regulation of cardiac muscle fiber development; and striated muscle cell development. Located in M band. Is expressed in cardiovascular system; musculature system; segmental plate; somite; and tail bud. Orthologous to human SMYD1 (SET and MYND domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 42 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b212 | unknown | Unknown | Unknown | ENU | |
| sa15678 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34269 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tm123a | Allele with one insertion | Intron 1 | Splice Site, Premature Stop | ENU | |
| to241a | unknown | Unknown | Unknown | ENU | |
| zf340 | Allele with one point mutation | Exon 2 | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-smyd1b | Cai et al., 2019 | |
| MO1-smyd1b | N/A | (5) |
| MO2-smyd1b | N/A | (3) |
| MO3-smyd1b | N/A | Tan et al., 2006 |
| MO4-smyd1b | N/A | (2) |
| MO5-smyd1b | N/A | Just et al., 2011 |
| MO6-smyd1b | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone-lysine N-methyltransferase | SET domain | SET domain superfamily | SMYD1, SET domain | Tetratricopeptide-like helical domain superfamily | Zinc finger, MYND-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q2MJQ9 | InterPro | 486 | ||||||
| UniProtKB:Q2MJQ8 | InterPro | 473 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
smyd1b-201
(1)
|
Ensembl | 1,422 nt | ||
| mRNA |
smyd1b-202
(1)
|
Ensembl | 1,819 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(smyd1b:smyd1b-MYC) |
|
|
| 1 | (7) |
| Tg2(eef1a1l1:smyd1b-GFP) |
|
| 1 | Xu et al., 2024 | |
| Tg2(smyd1b:smyd1b-MYC) |
|
|
| 1 | (5) |
| Tg(eef1a1l1:smyd1b-GFP) |
|
| 1 | (4) | |
| Tg(smyd1b:Cca.M3-ck) |
|
| 1 | (2) | |
| Tg(smyd1b:GFP) |
|
| 1 | (3) | |
| Tg(unc45b:smyd1b-EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-368O6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-14C17 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-335G10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194837 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039636 (1) | 1461 nt | ||
| Genomic | GenBank:CT027631 | 194262 nt | ||
| Polypeptide | UniProtKB:Q2MJQ9 (1) | 486 aa |
- Prill, K., Windsor Reid, P., Pilgrim, D. (2025) Heart Morphogenesis Requires Smyd1b for Proper Incorporation of the Second Heart Field in Zebrafish. Genes. 16:
- Xiao, H., Li, M., Zhong, Y., Patel, A., Xu, R., Zhang, C., Athey, T.W., Fang, S., Xu, T., Du, S. (2025) Hsf1 is essential for proteotoxic stress response in smyd1b-deficient embryos and fish survival under heat shock. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 39:e70283e70283
- Xu, R., Li, S., Chien, C.J., Zhong, Y., Xiao, H., Fang, S., Du, S. (2024) Expression of Smyd1b_tv1 by Alternative Splicing in Cardiac Muscle is Critical for Sarcomere Organization in Cardiomyocytes and Heart Function. Molecular and cellular biology. 44(12):543-561
- Livne, H., Avital, T., Ruppo, S., Harazi, A., Mitrani-Rosenbaum, S., Daya, A. (2022) Generation and characterization of a novel gne Knockout Model in Zebrafish. Frontiers in cell and developmental biology. 10:976111
- Jiao, S., Xu, R., Du, S. (2021) Smyd1 is essential for myosin expression and sarcomere organization in craniofacial, extraocular, and cardiac muscles. Journal of genetics and genomics = Yi chuan xue bao. 48(3):208-218
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Xu, R., Du, S. (2021) Overexpression of Lifeact-GFP Disrupts F-Actin Organization in Cardiomyocytes and Impairs Cardiac Function. Frontiers in cell and developmental biology. 9:746818
- Han, C.R., Wang, H., Hoffmann, V., Zerfas, P., Kruhlak, M., Cheng, S.Y. (2020) Thyroid hormone receptor α mutations cause heart defects in zebrafish. Thyroid : official journal of the American Thyroid Association. 31(2):315-326
- She, P., Zhang, H., Peng, X., Sun, J., Gao, B., Zhou, Y., Zhu, X., Hu, X., Lai, K.S., Wong, J., Zhou, B., Wang, L., Zhong, T.P. (2020) The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. Development (Cambridge, England). 147(18):
- Shi, Y., Li, Y., Wang, Y., Zhu, P., Chen, Y., Wang, H., Yue, S., Xia, X., Chen, J., Jiang, Z., Zhou, C., Cai, W., Yuan, H., Wu, Y., Wan, Y., Li, X., Zhu, X., Zhou, Z., Dai, G., Li, F., Mo, X., Ye, X., Fan, X., Zhuang, J., Wu, X., Yuan, W. (2020) BVES downregulation in non-syndromic tetralogy of fallot is associated with ventricular outflow tract stenosis. Scientific Reports. 10:14167
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