Gene
foxl2a
- ID
- ZDB-GENE-060512-241
- Name
- forkhead box L2a
- Symbol
- foxl2a Nomenclature History
- Previous Names
-
- foxl2
- zgc:136549
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within fourth ventricle development; maintenance of animal organ identity; and midbrain-hindbrain boundary development. Predicted to be located in nucleus. Is expressed in several structures, including blood vessel; gonad; hypoblast; male organism; and paraxial mesoderm. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome; lung non-small cell carcinoma; and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-foxl2a | Xu et al., 2018 | |
TALEN1-foxl2a | (2) | |
TALEN1-foxl2b | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
blepharophimosis, ptosis, and epicanthus inversus syndrome | Alliance | Blepharophimosis, epicanthus inversus, and ptosis, types 1 and 2 | 110100 |
primary ovarian insufficiency 3 | Alliance | Premature ovarian failure 3 | 608996 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018122 | Fork head domain conserved site1 |
Conserved_site | IPR030456 | Fork head domain conserved site 2 |
Domain | IPR001766 | Fork head domain |
Domain | IPR047515 | Forkhead box protein L2, forkhead domain |
Family | IPR050211 | Forkhead box domain-containing protein |
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Domain Details Per Protein
Protein | Additional Resources | Length | Forkhead box domain-containing protein | Forkhead box protein L2, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q1JPV2 | InterPro | 306 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
foxl2a-201
(1)
|
Ensembl | 1,057 nt | ||
mRNA |
foxl2a-202
(1)
|
Ensembl | 403 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-232G7 | ZFIN Curated Data | |
Encodes | cDNA | MGC:136549 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001045252 (1) | 1065 nt | ||
Genomic | GenBank:AL929010 (1) | 149319 nt | ||
Polypeptide | UniProtKB:Q1JPV2 (1) | 306 aa |
- Shi, C., Zhang, Y., Lu, Y., Lou, Q., Shang, G., Peng, X., Dai, X., Jin, X., He, J., Zhai, G., Yin, Z. (2025) Insights into the role of Fsh signaling in ovarian differentiation of chorionic gonadotropin α ( cgα)-deficient zebrafish. Zoological research. 46:695708695-708
- Wang, Y., Xu, G., Li, H., Gao, J., Du, X., Jiang, W., Ji, G., Liu, Z. (2025) Zglp-1 is a novel essential transcriptional regulator for sex reversal in zebrafish. Marine life science & technology. 7:256270256-270
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39
- Zhou, J., Yang, Y.J., Gan, R.H., Wang, Y., Li, Z., Zhang, X.J., Gui, J.F., Zhou, L. (2022) Foxl2a and Foxl2b are involved in midbrain-hindbrain boundary development in zebrafish. Gene expression patterns : GEP. 46:119286
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Pierron, F., Lorioux, S., Héroin, D., Daffe, G., Etcheverria, B., Cachot, J., Morin, B., Dufour, S., Gonzalez, P. (2021) Transgenerational epigenetic sex determination: Environment experienced by female fish affects offspring sex ratio. Environmental pollution (Barking, Essex : 1987). 277:116864
- Tarashansky, A.J., Musser, J.M., Khariton, M., Li, P., Arendt, D., Quake, S.R., Wang, B. (2021) Mapping single-cell atlases throughout Metazoa unravels cell type evolution. eLIFE. 10:
- Bereketoglu, C., Pradhan, A., Olsson, P.E. (2020) Nonsteroidal anti-inflammatory drugs (NSAIDs) cause male-biased sex differentiation in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 223:105476
- Ichino, N., Serres, M.R., Urban, R.M., Urban, M.D., Treichel, A.J., Schaefbauer, K.J., Greif, L.E., Varshney, G.K., Skuster, K.J., McNulty, M.S., Daby, C.L., Wang, Y., Liao, H.K., El-Rass, S., Ding, Y., Liu, W., Anderson, J.L., Wishman, M.D., Sabharwal, A., Schimmenti, L.A., Sivasubbu, S., Balciunas, D., Hammerschmidt, M., Farber, S.A., Wen, X.Y., Xu, X., McGrail, M., Essner, J.J., Burgess, S.M., Clark, K.J., Ekker, S.C. (2020) Building the vertebrate codex using the gene breaking protein trap library. eLIFE. 9:
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