Gene
ano2b
- ID
- ZDB-GENE-060503-62
- Name
- anoctamin 2b
- Symbol
- ano2b Nomenclature History
- Previous Names
-
- ano2
- si:dkey-224k5.2
- tmem16b (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in dorsal habenular nucleus. Orthologous to human ANO2 (anoctamin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nhi9 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| sa20190 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31370 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31371 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33366 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33367 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40208 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40209 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Anoctamin | Anoctamin, dimerisation domain | Anoctamin, transmembrane domain |
|---|---|---|---|---|---|
| UniProtKB:A0A2R8RJ22 | InterPro | 1065 | |||
| UniProtKB:A0A0R4IKC5 | InterPro | 998 | |||
| UniProtKB:A0A8M3ARC6 | InterPro | 1036 | |||
| UniProtKB:A0AB32TPI6 | InterPro | 1052 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-60D22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-224K5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171498 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327858 (1) | 4287 nt | ||
| Genomic | GenBank:CU468826 (2) | 180804 nt | ||
| Polypeptide | UniProtKB:A0A2R8RJ22 (1) | 1065 aa |
- Zhu, H., Zhang, X., Xu, S., Wu, J., Hou, M., Zhao, H., Zhou, Q., Zhong, X. (2022) Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 338(5):301-313
- Dayal, A., Ng, S.F.J., Grabner, M. (2019) Ca2+-activated Cl- channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration. Nature communications. 10:115
- Roberson, S., Halpern, M.E. (2017) Convergence of signaling pathways underlying habenular formation and axonal outgrowth. Development (Cambridge, England). 144(14):2652-2662
- Kuan, Y.S., Roberson, S., Akitake, C.M., Fortuno, L., Gamse, J., Moens, C., Halpern, M.E. (2015) Distinct requirements for Wntless in habenular development. Developmental Biology. 406(2):117-28
- deCarvalho, T.N., Subedi, A., Rock, J., Harfe, B.D., Thisse, C., Thisse, B., Halpern, M.E., Hong, E. (2014) Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis (New York, N.Y. : 2000). 52(6):636-55
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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