Gene
slc12a10.3
- ID
- ZDB-GENE-060503-518
- Name
- solute carrier family 12 member 10, tandem duplicate 3
- Symbol
- slc12a10.3 Nomenclature History
- Previous Names
-
- si:dkey-114c3.3
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable sodium:potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in eye and kidney.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11857 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16613 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17412 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40826 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004841 | Amino acid permease/ SLC12A domain |
| Domain | IPR018491 | SLC12A transporter, C-terminal |
| Family | IPR002948 | Thiazide-sensitive Na-K-Cl co-transporter |
| Family | IPR004842 | SLC12A transporter family |
| Homologous_superfamily | IPR023298 | P-type ATPase, transmembrane domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Amino acid permease/ SLC12A domain | P-type ATPase, transmembrane domain superfamily | SLC12A transporter, C-terminal | SLC12A transporter family | Thiazide-sensitive Na-K-Cl co-transporter |
|---|---|---|---|---|---|---|---|
| UniProtKB:B5DE35 | InterPro | 965 | |||||
| UniProtKB:A0A8M9QH36 | InterPro | 1001 | |||||
| UniProtKB:A0A8M1NLD8 | InterPro | 996 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc12a10.3-201
(1)
|
Ensembl | 4,116 nt | ||
| mRNA |
slc12a10.3-202
(1)
|
Ensembl | 4,187 nt | ||
| mRNA |
slc12a10.3-203
(1)
|
Ensembl | 719 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-114C3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175183 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001135131 (1) | 4198 nt | ||
| Genomic | GenBank:CR383683 (1) | 153095 nt | ||
| Polypeptide | UniProtKB:A0A8M9QH36 (1) | 1001 aa |
No data available
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, Y.F., Yan, J.J., Tseng, Y.C., Chen, R.D., Hwang, P.P. (2015) Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. International journal of biological sciences. 11:1190-203
- Hsu, H.H., Lin, L.Y., Tseng, Y.C., Horng, J.L., Hwang, P.P. (2014) A new model for fish ion regulation: identification of ionocytes in freshwater- and seawater-acclimated medaka (Oryzias latipes). Cell and tissue research. 357(1):225-43
- Wang, Y.F., Tseng, Y.C., Yan, J.J., Hiroi, J., and Hwang, P.P. (2009) Role of SLC12A10.2, a Na-Cl cotransporter-like protein, in a Cl uptake mechanism in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1650-R1660
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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