Gene
slc12a10.3
- ID
- ZDB-GENE-060503-518
- Name
- solute carrier family 12 member 10, tandem duplicate 3
- Symbol
- slc12a10.3 Nomenclature History
- Previous Names
-
- si:dkey-114c3.3
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable sodium:potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in eye and kidney.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11857 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16613 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17412 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40826 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004841 | Amino acid permease/ SLC12A domain |
| Domain | IPR018491 | SLC12A transporter, C-terminal |
| Family | IPR002948 | Thiazide-sensitive Na-K-Cl co-transporter |
| Family | IPR004842 | SLC12A transporter family |
| Homologous_superfamily | IPR023298 | P-type ATPase, transmembrane domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Amino acid permease/ SLC12A domain | P-type ATPase, transmembrane domain superfamily | SLC12A transporter, C-terminal | SLC12A transporter family | Thiazide-sensitive Na-K-Cl co-transporter |
|---|---|---|---|---|---|---|---|
| UniProtKB:B5DE35 | InterPro | 965 | |||||
| UniProtKB:A0A8M9QH36 | InterPro | 1001 | |||||
| UniProtKB:A0A8M1NLD8 | InterPro | 996 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc12a10.3-201
(1)
|
Ensembl | 4,116 nt | ||
| mRNA |
slc12a10.3-202
(1)
|
Ensembl | 4,187 nt | ||
| mRNA |
slc12a10.3-203
(1)
|
Ensembl | 719 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-114C3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175183 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001135131 (1) | 4198 nt | ||
| Genomic | GenBank:CR383683 (1) | 153095 nt | ||
| Polypeptide | UniProtKB:A0A8M9QH36 (1) | 1001 aa |
No data available
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, Y.F., Yan, J.J., Tseng, Y.C., Chen, R.D., Hwang, P.P. (2015) Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. International journal of biological sciences. 11:1190-203
- Hsu, H.H., Lin, L.Y., Tseng, Y.C., Horng, J.L., Hwang, P.P. (2014) A new model for fish ion regulation: identification of ionocytes in freshwater- and seawater-acclimated medaka (Oryzias latipes). Cell and tissue research. 357(1):225-43
- Wang, Y.F., Tseng, Y.C., Yan, J.J., Hiroi, J., and Hwang, P.P. (2009) Role of SLC12A10.2, a Na-Cl cotransporter-like protein, in a Cl uptake mechanism in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1650-R1660
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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