Gene
tfpi2
- ID
- ZDB-GENE-060503-38
- Name
- tissue factor pathway inhibitor 2
- Symbol
- tfpi2 Nomenclature History
- Previous Names
-
- si:ch211-262k23.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including heart development; regulation of hemopoiesis; and sarcomere organization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; eye; heart; liver; and ovary. Human ortholog(s) of this gene implicated in acute myeloid leukemia and retinal degeneration. Orthologous to human TFPI2 (tissue factor pathway inhibitor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Zhang et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020901 | Proteinase inhibitor I2, Kunitz, conserved site |
| Domain | IPR002223 | Pancreatic trypsin inhibitor Kunitz domain |
| Family | IPR008296 | Tissue factor pathway inhibitor-like |
| Family | IPR050098 | Tissue factor pathway inhibitor/Kunitz-type serine protease inhibitor-like |
| Homologous_superfamily | IPR036880 | Pancreatic trypsin inhibitor Kunitz domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Pancreatic trypsin inhibitor Kunitz domain | Pancreatic trypsin inhibitor Kunitz domain superfamily | Proteinase inhibitor I2, Kunitz, conserved site | Tissue factor pathway inhibitor/Kunitz-type serine protease inhibitor-like | Tissue factor pathway inhibitor-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q1WCN6 | InterPro | 233 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-120E1 | ZFIN Curated Data | |
| Contained in | BAC | CH211-262K23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153805 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191502 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040096 (1) | 1666 nt | ||
| Genomic | GenBank:BX537314 (1) | 168538 nt | ||
| Polypeptide | UniProtKB:Q1WCN6 (1) | 233 aa |
- Gistelinck, C., Gioia, R., Gagliardi, A., Tonelli, F., Marchese, L., Bianchi, L., Landi, C., Bini, L., Huysseune, A., Witten, P.E., Staes, A., Gevaert, K., De Rocker, N., Menten, B., Malfait, F., Leikin, S., Carra, S., Tenni, R., Rossi, A., De Paepe, A., Coucke, P., Willaert, A., Forlino, A. (2016) Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Scientific Reports. 6:21540
- Zhang, Y., Wang, H., Zhang, J., Zheng, F., Jiang, N., Ma, D. (2015) Tissue factor pathway inhibitor-2 is critical in zebrafish cardiogenesis. Biochemical and Biophysical Research Communications. 456(3):827-33
- Zhang, Y., Wang, L., Zhou, W., Wang, H., Zhang, J., Deng, S., Li, W., Li, H., Mao, Z., and Ma, D. (2013) Tissue factor pathway inhibitor-2: A novel gene involved in zebrafish central nervous system development. Developmental Biology. 381(1):38-49
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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