Gene
mpl
- ID
- ZDB-GENE-060421-1
- Name
- MPL proto-oncogene, thrombopoietin receptor
- Symbol
- mpl Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor activity. Acts upstream of or within thrombocyte differentiation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in blood; nucleate erythrocyte; thrombocyte; and ventral wall of dorsal aorta. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia 1; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb831 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
| sa881 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20736 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26776 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sm10 | Allele with one delins | Exon 3 | Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mpl | Kc et al., 2016 | |
| CRISPR2-mpl | Zebrafish Nomenclature Committee | |
| CRISPR3-mpl | Zebrafish Nomenclature Committee | |
| MO1-mpl | N/A | (4) |
| TALEN1-mpl | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital amegakaryocytic thrombocytopenia 1 | Alliance | Amegakaryocytic thrombocytopenia, congenital, 1 | 604498 |
| essential thrombocythemia | Alliance | Thrombocythemia 2 | 601977 |
| myelofibrosis | Alliance | Myelofibrosis with myeloid metaplasia, somatic | 254450 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Domain | IPR015152 | Growth hormone/erythropoietin receptor, ligand binding |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Growth hormone/erythropoietin receptor, ligand binding | Immunoglobulin-like fold | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BDQ1 | InterPro | 641 | |||||
| UniProtKB:Q6EIY6 | InterPro | 614 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(mpl:EGFP) |
|
| 2 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-175H18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193835 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193839 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003858 (1) | 2086 nt | ||
| Genomic | GenBank:AL807381 (1) | 230718 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDQ1 (1) | 641 aa |
- Spampinato, M., Giallongo, C., Giallongo, S., Spina, E., Duminuco, A., Longhitano, L., Caltabiano, R., Salvatorelli, L., Broggi, G., Pricoco, E.P., Del Fabro, V., Dulcamare, I., DI Mauro, A.M., Romano, A., Di Raimondo, F., Li Volti, G., Palumbo, G.A., Tibullo, D. (2025) Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis. Journal of translational medicine. 23:6969
- Li, M., Wang, R., Yan, T., Tao, X., Gao, S., Wang, Z., Chai, Y., Qiu, S., Chen, W. (2024) Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway. British journal of pharmacology. 182(4):1090-1106
- Ling, Y., Wu, J., Liu, Y., Meng, P., Sun, Y., Zhao, D., Lin, Q. (2024) Establishment of a Diamond-Blackfan anemia like model in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(10):906-921
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Lei, W., Liu, Z., Su, Z., Meng, P., Zhou, C., Chen, X., Hu, Z., Xiao, A., Zhou, M., Huang, L., Zhang, Y., Qin, X., Wang, J., Zhu, F., Nie, J. (2023) Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis. Journal of Hematology & Oncology. 16:8484
- Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727
- Kimura, K., Yamamori, S., Hazawa, M., Kobayashi-Sun, J., Kondo, M., Wong, R.W., Kobayashi, I. (2022) Inhibition of canonical Wnt signaling promotes ex vivo maintenance and proliferation of hematopoietic stem cells in zebrafish. Stem cells (Dayton, Ohio). 40(9):831-842
- Yang, L., Wu, L., Meng, P., Zhang, X., Zhao, D., Lin, Q., Zhang, Y. (2022) Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish. Journal of thrombosis and haemostasis : JTH. 20(8):1900-1909
- Belmonte, R.L., Engbretson, I.L., Kim, J.H., Cajias, I., Ahn, E.E., Stachura, D.L. (2021) son is necessary for proper vertebrate blood development. PLoS One. 16:e0247489
- Bresciani, E., Carrington, B., Yu, K., Kim, E.M.K., Zhen, T., Guzman, V.S., Broadbridge, E., Bishop, K., Kirby, M., Harper, U., Wincovitch, S., Dell'Orso, S., Sartorelli, V., Sood, R., Liu, P.P. (2021) Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. Blood advances. 5(23):4949-4962
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