Gene
cubn
- ID
- ZDB-GENE-060228-6
- Name
- cubilin (intrinsic factor-cobalamin receptor)
- Symbol
- cubn Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in cell differentiation. Predicted to act upstream of or within cholesterol metabolic process and protein transport. Predicted to be located in apical plasma membrane; endosome; and lysosomal membrane. Predicted to be active in extracellular space. Is expressed in pleuroperitoneal region. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Park et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
megaloblastic anemia | Alliance | Imerslund-Grasbeck syndrome 1 | 261100 |
[Proteinuria, chronic benign] | 618884 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | CUB domain | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | NOTCH1 EGF-like calcium-binding domain | Spermadhesin, CUB domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PME6 | InterPro | 3626 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-48E2 | ZFIN Curated Data | |
Contained in | BAC | CH211-204I4 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_021470374 (1) | 11214 nt | ||
Genomic | GenBank:BX000366 (2) | 169542 nt | ||
Polypeptide | UniProtKB:A0A8M9PME6 (1) | 3626 aa |
- Childers, L., Park, J., Wang, S., Liu, R., Barry, R., Watts, S.A., Rawls, J.F., Bagnat, M. (2025) Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome. eLIFE. 13:
- Park, J., Levic, D.S., Sumigray, K.D., Bagwell, J., Eroglu, O., Block, C.L., Eroglu, C., Barry, R., Lickwar, C.R., Rawls, J.F., Watts, S.A., Lechler, T., Bagnat, M. (2019) Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. Developmental Cell. 51(1):7-20.e6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Chowanadisai, W. (2014) Comparative Genomic Analysis of slc39a12/ZIP12: Insight into a Zinc Transporter Required for Vertebrate Nervous System Development. PLoS One. 9:e111535
- McCampbell, K.K., Springer, K.N., Wingert, R.A. (2014) Analysis of nephron composition and function in the adult zebrafish kidney. Journal of visualized experiments : JoVE. (90):e51644
- Anzenberger, U., Bit-Avragim, N., Rohr, S., Rudolph, F., Dehmel, B., Willnow, T.E., and Abdelilah-Seyfried, S. (2006) Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros. Journal of Cell Science. 119(10):2127-2137
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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