Gene
ifng1r
- ID
- ZDB-GENE-060210-1
- Name
- interferon gamma related
- Symbol
- ifng1r Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and type II interferon receptor binding activity. Acts upstream of or within defense response to Gram-negative bacterium and immune response. Predicted to be located in extracellular space. Is expressed in digestive system; gill; reproductive system; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including ataxia telangiectasia; autoimmune disease (multiple); eczema herpeticum; leukemia (multiple); and liver disease (multiple). Orthologous to human IFNG (interferon gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sieger et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb209 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb210 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa1406 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12073 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18777 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ifng1r | Zebrafish Nomenclature Committee | |
| CRISPR2-ifng1r | Zhou et al., 2018 | |
| CRISPR3-ifng1r | Zhou et al., 2018 | |
| MO1-ifng1r | N/A | (5) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aplastic anemia | Alliance | {Aplastic anemia} | 609135 |
| immunodeficiency 69 | Alliance | ?Immunodeficiency 69, mycobacteriosis | 618963 |
| tuberous sclerosis 2 | Alliance | {TSC2 angiomyolipomas, renal, modifier of} | 613254 |
| {AIDS, rapid progression to} | 609423 | ||
| {Hepatitis C virus, response to therapy of} | 609532 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Interferon gamma |
|---|---|---|---|---|
| UniProtKB:Q5TLE6 | InterPro | 170 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ifng1r-201
(1)
|
Ensembl | 513 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-266A5 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020793 (1) | 513 nt | ||
| Genomic | GenBank:BX465210 (1) | 171708 nt | ||
| Polypeptide | UniProtKB:Q5TLE6 (1) | 170 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Li, J., Gao, J., Gao, Y., Shi, C., Guo, X., Huang, H., Wang, J., Huang, X., Chen, H., Huang, J., Wang, W., Yang, H. (2024) Degarelix limits the survival of mycobacteria and granuloma formation. Microbial pathogenesis. 197:107046
- Liang, H., Li, M., Chen, J., Zhou, W., Xia, D., Ding, Q., Yang, Y., Zhang, Z., Ran, C., Zhou, Z. (2024) The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish. Microbiome. 12:244244
- Ernst, A., Piragyte, I., Mp, A.M., Le, N.D., Grandgirard, D., Leib, S.L., Oates, A., Mercader, N. (2023) Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform. Scientific Reports. 13:1703717037
- Gao, Y., Li, J., Guo, X., Guan, L., Wang, J., Huang, X., Wang, W., Yang, H. (2023) L-Tyrosine Limits Mycobacterial Survival in Tuberculous Granuloma. Pathogens (Basel, Switzerland). 12(5):
- Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727
- Viana, F., Boucontet, L., Laghi, V., Schator, D., Ibranosyan, M., Jarraud, S., Colucci-Guyon, E., Buchrieser, C. (2023) Hiding in the yolk: A unique feature of Legionella pneumophila infection of zebrafish. PLoS pathogens. 19:e1011375e1011375
- Chen, S.N., Gan, Z., Hou, J., Yang, Y.C., Huang, L., Huang, B., Wang, S., Nie, P. (2022) Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Nature communications. 13:999
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Tyrkalska, S.D., Martínez-López, A., Arroyo, A.B., Martínez-Morcillo, F.J., Candel, S., García-Moreno, D., Mesa-Del-Castillo, P., Cayuela, M.L., Mulero, V. (2022) Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern. Science advances. 8:eabo0732
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