Gene
lama1
- ID
- ZDB-GENE-060118-1
- Name
- laminin, alpha 1
- Symbol
- lama1 Nomenclature History
- Previous Names
-
- bal
- bashful
- zmp:0000000656 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to be an extracellular matrix structural constituent. Acts upstream of or within several processes, including camera-type eye development; nervous system development; and notochord cell development. Predicted to be located in cell junction and extracellular region. Predicted to be part of laminin complex. Predicted to be active in basement membrane. Is expressed in several structures, including central nervous system; eye; immature eye; pronephros; and trunk. Orthologous to human LAMA1 (laminin subunit alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 70 figures from 19 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a69 | Allele with one point mutation | Unknown | Missense | not specified | |
| b765 | unknown | Unknown | Unknown | not specified | |
| lama1_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| m102 | unknown | Unknown | Unknown | ENU | |
| m113 | unknown | Unknown | Unknown | ENU | |
| m190 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| m255 | unknown | Unknown | Unknown | ENU | |
| m268 | unknown | Unknown | Unknown | ENU | |
| m277 | unknown | Unknown | Unknown | ENU | |
| m290 | unknown | Unknown | Unknown | ENU |
1 - 10 of 39
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-lama1 | N/A | (4) |
| MO2-lama1 | N/A | (7) |
| MO3-lama1 | N/A | Pollard et al., 2006 |
| MO4-lama1 | N/A | Pollard et al., 2006 |
| MO5-lama1 | N/A | (4) |
| MO6-lama1 | N/A | Zinkevich et al., 2006 |
1 - 6 of 6
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Poretti-Boltshauser syndrome | 615960 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | Laminin alpha, domain I | Laminin domain II | Laminin G domain | Laminin IV | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q45H72 | InterPro | 3075 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(lama1:EGFP) |
|
| 1 | Pickering et al., 2017 | |
| TgBAC(lama1:lama1-Dendra) |
|
|
| 1 | Soans et al., 2022 |
| TgBAC(lama1:lama1-EGFP) |
|
|
| 1 | Pickering et al., 2017 |
| TgBAC(lama1:lama1-mKate2) |
|
|
| 1 | Soans et al., 2022 |
| TgBAC(lama1:lama1-sfGFP) |
|
|
| 1 | Soans et al., 2022 |
1 - 5 of 5
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-38N6 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001034986 (1) | 9582 nt | ||
| Genomic | GenBank:FP101885 (1) | 130902 nt | ||
| Polypeptide | UniProtKB:Q45H72 (1) | 3075 aa |
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Falat, E.J., Voit, G.C., Gutzman, J.H. (2022) Laminin-111 mutant studies reveal a hierarchy within laminin-111 genes in their requirement for basal epithelial tissue folding. Developmental Biology. 492:172-186
- Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
- Soans, K.G., Ramos, A.P., Sidhaye, J., Krishna, A., Solomatina, A., Hoffmann, K.B., Schlüßler, R., Guck, J., Sbalzarini, I.F., Modes, C.D., Norden, C. (2022) Collective cell migration during optic cup formation features changing cell-matrix interactions linked to matrix topology. Current biology : CB. 32(22):4817-4831.e9
- Zhao, N., Wang, X., Wang, T., Xu, X., Liu, Q., Li, J. (2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). International Journal of Molecular Sciences. 23(18)
- Geusz, R.J., Wang, A., Chiou, J., Lancman, J.J., Wetton, N., Kefalopoulou, S., Wang, J., Qui, Y., Yan, J., Aylward, A., Ren, B., Dong, P.D.S., Gaulton, K.J., Sander, M. (2021) Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. eLIFE. 10
- Carney, K.R., Bryan, C.D., Gordon, H.B., Kwan, K.M. (2020) LongAxis: A MATLAB-based program for 3D quantitative analysis of epithelial cell shape and orientation. Developmental Biology. 458:1-11
- Chaudhury, S., Okuda, K.S., Koltowska, K., Lagendijk, A.K., Paterson, S., Baillie, G.J., Simons, C., Smith, K.A., Hogan, B.M., Bower, N.I. (2020) Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo. Development (Cambridge, England). 147(18):
- Liu, D.J., Zhang, F., Chen, Y., Jin, Y., Zhang, Y.L., Chen, S.B., Xie, Y.Y., Huang, Q.H., Zhao, W.L., Wang, L., Xu, P.F., Chen, Z., Chen, S.J., Li, B., Zhang, A., Sun, X.J. (2020) setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell discovery. 6:72
- Mukherjee, D., Wagh, G., Mokalled, M.H., Kontarakis, Z., Dickson, A.L., Rayrikar, A., Günther, S., Poss, K.D., Stainier, D.Y.R., Patra, C. (2020) Ccn2a/Ctgfa is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. Development (Cambridge, England). 148(2):
1 - 10 of 60
Show