Gene
grna.1
- ID
- ZDB-GENE-060103-1
- Name
- granulin a, tandem duplicate 1
- Symbol
- grna.1 Nomenclature History
- Previous Names
-
- grn1
- zgc:136318
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; epidermis; gill; heart; and pleuroperitoneal region.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu903 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-grna.1 | Zebrafish Nomenclature Committee | |
| MO1-grna.1 | N/A | Tsuruma et al., 2018 |
| MO2-grna.1 | N/A | Tsuruma et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Granulin | Granulin family | Granulin superfamily |
|---|---|---|---|---|---|
| UniProtKB:A8E5C4 | InterPro PDB | 147 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-173P18 | ZFIN Curated Data | |
| Encodes | EST | eu903 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:136318 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174265 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:GDQH01001517 (1) | 1619 nt | ||
| Genomic | GenBank:BX510986 | 157245 nt | ||
| Polypeptide | UniProtKB:A8E5C4 (1) | 147 aa |
No data available
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Hsu, A.Y., Wang, T., Syahirah, R., Liu, S., Li, K., Zhang, W., Wang, J., Cao, Z., Tian, S., Matosevic, S., Staiger, C.J., Wan, J., Deng, Q. (2022) Rora Regulates Neutrophil Migration and Activation in Zebrafish. Frontiers in immunology. 13:756034
- Kamel, S.M., van Opbergen, C.J.M., Koopman, C.D., Verkerk, A.O., Boukens, B.J.D., de Jonge, B., Onderwater, Y.L., van Alebeek, E., Chocron, S., Polidoro Pontalti, C., Weuring, W.J., Vos, M.A., de Boer, T.P., van Veen, T.A.B., Bakkers, J. (2021) Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy. Nature communications. 12:7151
- Ma, H., Liu, Z., Yang, Y., Feng, D., Dong, Y., Garbutt, T.A., Hu, Z., Wang, L., Luan, C., Cooper, C.D., Li, Y., Welch, J.D., Qian, L., Liu, J. (2021) Functional coordination of non-myocytes plays a key role in adult zebrafish heart regeneration. EMBO reports. 22(11):e52901
- Silva, N.J., Dorman, L.C., Vainchtein, I.D., Horneck, N.C., Molofsky, A.V. (2021) In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Nature communications. 12:5916
- Zhu, J., Xu, H., Song, H., Li, X., Wang, N., Zhao, J., Zheng, X., Kim, K.Y., Zhang, H., Mao, Q., Xia, H. (2021) CRISPR/Cas9-mediated grna gene knockout leads to neurodevelopmental defects and motor behavior changes in zebrafish. Journal of neurochemistry. 157(3):520-531
- Mukherjee, D., Wagh, G., Mokalled, M.H., Kontarakis, Z., Dickson, A.L., Rayrikar, A., Günther, S., Poss, K.D., Stainier, D.Y.R., Patra, C. (2020) Ccn2a/Ctgfa is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. Development (Cambridge, England). 148(2):
- Rougeot, J., Torraca, V., Zakrzewska, A., Kanwal, Z., Jansen, H.J., Sommer, F., Spaink, H.P., Meijer, A.H. (2019) RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in immunology. 10:832
- Tsuruma, K., Saito, Y., Okuyoshi, H., Yamaguchi, A., Shimazawa, M., Goldman, D., Hara, H. (2018) Granulin 1 Promotes Retinal Regeneration in Zebrafish. Investigative ophthalmology & visual science. 59:6057-6066
- Wang, P., Chitramuthu, B., Bateman, A., Bennett, H.P.J., Xu, P., Ni, F. (2018) Structure Dissection of Zebrafish Progranulins Identifies a Well-Folded Granulin/Epithelin Module Protein with pro-Cell Survival Activities. Protein science : a publication of the Protein Society. 27(8):1476-1490
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