Gene
smyd3
- ID
- ZDB-GENE-051120-138
- Name
- SET and MYND domain containing 3
- Symbol
- smyd3 Nomenclature History
- Previous Names
-
- zgc:123202
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K4 trimethyltransferase activity. Acts upstream of or within heart morphogenesis; response to hypoxia; and skeletal muscle organ development. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; eye; heart; integument; and pleuroperitoneal region. Orthologous to human SMYD3 (SET and MYND domain containing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihbsm3 | Allele with one deletion | Exon 5 | Frameshift, Premature Stop | CRISPR | |
| ihbsm3b | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| la013021Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019911Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa36344 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42879 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-smyd3 | (3) | |
| MO1-smyd3 | N/A | (2) |
| MO2-smyd3 | N/A | Fujii et al., 2011 |
| MO3-smyd3 | N/A | Huang et al., 2013 |
| MO4-smyd3 | N/A | Kim et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone-lysine N-methyltransferase | SET domain | SET domain superfamily | Tetratricopeptide-like helical domain superfamily | Zinc finger, MYND-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q32LV8 | InterPro | 380 | |||||
| UniProtKB:A0AB13AB68 | InterPro | 428 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-112K18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-165N1 | ZFIN Curated Data | |
| Contained in | BAC | CH211-248N8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-1I9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-246M15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123202 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423732 (1) | 1495 nt | ||
| Genomic | GenBank:BX276117 (2) | 181677 nt | ||
| Polypeptide | UniProtKB:A0AB13AB68 (1) | 428 aa |
- Wang, Z., Chen, X., Zhu, C., Fan, S., Tang, J., Deng, H., Sun, X., Liu, X., Xiao, W. (2025) Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 122:e2320644122e2320644122
- Dalla Barba, F., Soardi, M., Mouhib, L., Risato, G., Akyürek, E.E., Lucon-Xiccato, T., Scano, M., Benetollo, A., Sacchetto, R., Richard, I., Argenton, F., Bertolucci, C., Carotti, M., Sandonà, D. (2023) Modeling Sarcoglycanopathy in Danio rerio. International Journal of Molecular Sciences. 24(16):
- Wang, Z., Chen, X., Fan, S., Zhu, C., Deng, H., Tang, J., Sun, X., Jia, S., Liao, Q., Xiao, W., Liu, X. (2022) Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity. The Journal of biological chemistry. 298(12):102633
- Fittipaldi, R., Floris, P., Proserpio, V., Cotelli, F., Beltrame, M., Caretti, G. (2021) The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Cells. 10(5):
- Cheng, Y., Lai, F., Wang, X., Shang, D., Zou, J., Luo, M., Xia, X., Cheng, H., Zhou, R. (2020) Srag regulates autophagy via integrating into a preexisting autophagy pathway in testis. Molecular Biology and Evolution. 38(1):128-141
- Fellous, A., Earley, R.L., Silvestre, F. (2018) The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 687:173-187
- Lebedeva, S., de Jesus Domingues, A.M., Butter, F., Ketting, R.F. (2017) Characterization of genetic loss-of-function of Fus in zebrafish. RNA Biology. 14(1):29-35
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kim, J.D., Kim, E., Koun, S., Ham, H.J., Rhee, M., Kim, M.J., Huh, T.L. (2015) Proper Activity of Histone H3 Lysine 4 (H3K4) Methyltransferase Is Required for Morphogenesis during Zebrafish Cardiogenesis. Molecules and cells. 38(6):580-6
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