Gene
hmgb2a
- ID
- ZDB-GENE-051120-126
- Name
- high mobility group box 2a
- Symbol
- hmgb2a Nomenclature History
- Previous Names
-
- hmgb2
- wu:fb22b10
- wu:fc95d12
- zgc:123215
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within DNA recombination; inflammatory response; and innate immune response. Predicted to be located in chromosome; cytoplasm; and extracellular region. Predicted to be active in nucleus. Is expressed in central nervous system; gut; neuromast; ovary; and pectoral fin bud. Orthologous to human HMGB2 (high mobility group box 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hmgb2a | Sun et al., 2019 | |
| CRISPR2-hmgb2a | Sun et al., 2019 | |
| MO1-hmgb2a | N/A | Itou et al., 2011 |
| MO2-hmgb2a | N/A | Itou et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | High Mobility Group Box (HMGB) |
|---|---|---|---|---|---|
| UniProtKB:Q32PT3 | InterPro | 213 | |||
| UniProtKB:A0A8M1N808 | InterPro | 213 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmgb2a-201
(1)
|
Ensembl | 1,237 nt | ||
| mRNA |
hmgb2a-202
(1)
|
Ensembl | 862 nt | ||
| mRNA |
hmgb2a-204
(1)
|
Ensembl | 377 nt | ||
| ncRNA |
hmgb2a-002
(1)
|
Ensembl | 269 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-28D11 | ZFIN Curated Data | |
| Contains | STS | chunp30321 | ||
| Encodes | EST | fb22b10 | ||
| Encodes | EST | fc95d12 | ||
| Encodes | cDNA | MGC:123215 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037424 (1) | 1104 nt | ||
| Genomic | GenBank:CU462871 (1) | 113169 nt | ||
| Polypeptide | UniProtKB:A0A8M1N808 (1) | 213 aa |
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Das, R.N., Tevet, Y., Safriel, S., Han, Y., Moshe, N., Lambiase, G., Bassi, I., Nicenboim, J., Brückner, M., Hirsch, D., Eilam-Altstadter, R., Herzog, W., Avraham, R., Poss, K.D., Yaniv, K. (2022) Generation of specialized blood vessels via lymphatic transdifferentiation. Nature. 606(7914):570-575
- Shen, W., Gong, B., Xing, C., Zhang, L., Sun, J., Chen, Y., Yang, C., Yan, L., Chen, L., Yao, L., Li, G., Deng, H., Wu, X., Meng, A. (2022) Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Cell. 185(26):4954-4970.e20
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Yu, S., He, J. (2019) Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish. eLIFE. 8
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Choi, T.Y., Khaliq, M., Tsurusaki, S., Ninov, N., Stainier, D.Y.R., Tanaka, M., Shin, D. (2017) Bmp Signaling Governs Biliary-Driven Liver Regeneration in Zebrafish via Tbx2b and Id2a. Hepatology (Baltimore, Md.). 66(5):1616-1630
- Rao, Y., Su, J., Yang, C., Peng, L., Feng, X., and Li, Q. (2013) Characterizations of two grass carp Ctenopharyngodon idella HMGB2 genes and potential roles in innate immunity. Developmental and comparative immunology. 41(2):164-177
- Cuello, S., Ximénez-Embún, P., Ruppen, I., Schonthaler, H.B., Ashman, K., Madrid, Y., Luque-Garcia, J.L., and Cámara, C. (2012) Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. The Analyst. 137(22):5302-5311
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