Gene

nedd4l

ID

ZDB-GENE-051118-2

Name

NEDD4 like E3 ubiquitin protein ligase

Symbol

nedd4l Nomenclature History

Previous Names

nedd4b (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable sodium channel inhibitor activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis and ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi apparatus and multivesicular body. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Bakkers et al., 2005

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nedd4l Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Periventricular nodular heterotopia 7	617201

Associated With nedd4l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR000569	HECT domain
Domain	IPR001202	WW domain
Family	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
Family	IPR050409	E3 ubiquitin-protein ligase
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036020	WW domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PQX6	InterPro	1277
UniProtKB:A0A8M9P3M1	InterPro	1277
UniProtKB:A0A8M9PD40	InterPro	1274
UniProtKB:A0A8M9PUG8	InterPro	1000
UniProtKB:A0A8M9P3L7	InterPro	1279
UniProtKB:A0A8M9PIR5	InterPro	1278
UniProtKB:A0A8M9PD36	InterPro	1278
UniProtKB:A0A8M9PIR9	InterPro	1273
UniProtKB:A0A8M9PUF7	InterPro	1278
UniProtKB:A0A8M2B803	InterPro	996
UniProtKB:A0A8M9PQY1	InterPro	1259
UniProtKB:A0A8M9P3M5	InterPro	1258
UniProtKB:A0A8M9PIS2	InterPro	1001
UniProtKB:A0A8M9PUG3	InterPro	1262
UniProtKB:A0A8M9PD44	InterPro	1018
UniProtKB:A0A8N7UQV5	InterPro	994
UniProtKB:A0AB32T885	InterPro	1272
UniProtKB:A0AB32T887	InterPro	1272
UniProtKB:A0AB32T9K6	InterPro	1253
UniProtKB:A0AB32TA00	InterPro	1013
UniProtKB:A0AB32TAS4	InterPro	1012
UniProtKB:A0AB32TB27	InterPro	1257
UniProtKB:A0AB32TBT6	InterPro	995
UniProtKB:A0AB32TDS1	InterPro	1254
UniProtKB:A0AB32TF36	InterPro	1273
UniProtKB:A0AB32TF92	InterPro	1273
UniProtKB:A0AB32TFL9	InterPro	1011

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nedd4l-201 (1) Ensembl	Ensembl	3,033 nt	Select Tool ZFIN BLAST
mRNA	nedd4l-202 (1) Ensembl	Ensembl	4,936 nt	Select Tool ZFIN BLAST
mRNA	nedd4l-203 (1) Ensembl	Ensembl	2,964 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations