Gene
nedd4l
- ID
- ZDB-GENE-051118-2
- Name
- NEDD4 like E3 ubiquitin protein ligase
- Symbol
- nedd4l Nomenclature History
- Previous Names
-
- nedd4b (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable sodium channel inhibitor activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis and ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi apparatus and multivesicular body. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Bakkers et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Periventricular nodular heterotopia 7 | 617201 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000008 | C2 domain |
Domain | IPR000569 | HECT domain |
Domain | IPR001202 | WW domain |
Family | IPR024928 | E3 ubiquitin-protein ligase, SMURF1 type |
Family | IPR050409 | E3 ubiquitin-protein ligase |
Homologous_superfamily | IPR035892 | C2 domain superfamily |
Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
Homologous_superfamily | IPR036020 | WW domain superfamily |
Domain Details Per Protein
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
nedd4l-201
(1)
|
Ensembl | 3,033 nt | ||
mRNA |
nedd4l-202
(1)
|
Ensembl | 4,936 nt | ||
mRNA |
nedd4l-203
(1)
|
Ensembl | 2,964 nt |
Interactions and Pathways
No data available
Plasmids
No data available