Gene

tcf3b

ID

ZDB-GENE-051113-64

Name

transcription factor 3b

Symbol

tcf3b Nomenclature History

Previous Names

tcf3a (1)
zgc:113045

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin. Is expressed in margin and telencephalon. Human ortholog(s) of this gene implicated in agammaglobulinemia 8A; agammaglobulinemia 8B; and colorectal cancer. Orthologous to human TCF3 (transcription factor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcf3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
agammaglobulinemia 8A	Alliance	Agammaglobulinemia 8A, autosomal dominant	616941
agammaglobulinemia 8B	Alliance	Agammaglobulinemia 8B, autosomal recessive	619824

Associated With tcf3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Family	IPR051098	Neuronal Differentiation E-box Binding Transcription Factors
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:B1H1L4	InterPro	652
UniProtKB:A0A8M2BHT8	InterPro	634
UniProtKB:A0A8M3AMB2	InterPro	651
UniProtKB:A0A8M3B5J8	InterPro	627
UniProtKB:A0A0R4IMI6	InterPro	635

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tcf3b-201 (1) Ensembl	Ensembl		6,424 nt	Select Tool ZFIN BLAST
mRNA	tcf3b-202 (1) Ensembl	Ensembl		6,373 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations