Gene
katnal2
- ID
- ZDB-GENE-051113-156
- Name
- katanin p60 subunit A-like 2
- Symbol
- katnal2 Nomenclature History
- Previous Names
-
- zgc:123350
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity. Acts upstream of or within social behavior. Predicted to be located in spindle pole. Predicted to be active in cytoplasm and spindle. Is expressed in brain. Used to study autism spectrum disorder. Orthologous to human KATNAL2 (katanin catalytic subunit A1 like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zheng et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Zheng et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017392Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa41606 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ya521 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| ya522 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| zf3701 | Allele with one delins | Exon 6 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-katnal2 | Zheng et al., 2022 | |
| CRISPR2-katnal2 | (2) | |
| CRISPR3-katnal2 | (2) | |
| CRISPR4-katnal2 | Weinschutz Mendes et al., 2023 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autism spectrum disorder | katnal2zf3701/zf3701 | standard conditions | Zheng et al., 2022 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, core | Katanin p60 ATPase-containing subunit A-like 2 | LIS1 homology motif | Microtubule-severing AAA ATPase | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q32PM7 | InterPro | 485 | |||||||
| UniProtKB:A0AB13A9T5 | InterPro | 525 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
katnal2-201
(1)
|
Ensembl | 1,418 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-262G12 | ||
| Encodes | cDNA | MGC:123350 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037414 (1) | 1904 nt | ||
| Genomic | GenBank:BX927402 (1) | 155963 nt | ||
| Polypeptide | UniProtKB:A0AB13A9T5 (1) | 525 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Ten Martin, D., Jardin, N., Vougny, J., Giudicelli, F., Gasmi, L., Berbée, N., Henriot, V., Lebrun, L., Haumaître, C., Kneussel, M., Nicol, X., Janke, C., Magiera, M.M., Hazan, J., Fassier, C. (2024) Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes. The EMBO journal. 44(1):107-140
- Weinschutz Mendes, H., Neelakantan, U., Liu, Y., Fitzpatrick, S.E., Chen, T., Wu, W., Pruitt, A., Jin, D.S., Jamadagni, P., Carlson, M., Lacadie, C.M., Enriquez, K.D., Li, N., Zhao, D., Ijaz, S., Sakai, C., Szi, C., Rooney, B., Ghosh, M., Nwabudike, I., Gorodezky, A., Chowdhury, S., Zaheer, M., McLaughlin, S., Fernandez, J.M., Wu, J., Eilbott, J.A., Vander Wyk, B., Rihel, J., Papademetris, X., Wang, Z., Hoffman, E.J. (2023) High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports. 42:112243112243
- Zheng, J., Long, F., Cao, X., Xiong, B., Li, Y. (2022) Knockout of Katnal2 Leads to Autism-like Behaviors and Developmental Delay in Zebrafish. International Journal of Molecular Sciences. 23(15)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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