Gene
slco2b1
- ID
- ZDB-GENE-051023-6
- Name
- solute carrier organic anion transporter family, member 2B1
- Symbol
- slco2b1 Nomenclature History
- Previous Names
-
- Oatp2b1 (1)
- im:7158298
- wu:fi40d02
- zgc:123236
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Acts upstream of or within hematopoietic stem cell proliferation and prostaglandin metabolic process. Predicted to be located in plasma membrane. Predicted to be active in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including gill; liver; pleuroperitoneal region; skeletal muscle; and ventral mesenchyme. Orthologous to human SLCO2B1 (solute carrier organic anion transporter family member 2B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158298 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Cacialli et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9418 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18539 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19270 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24017 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24018 | Allele with one point mutation | Unknown | Splice Site, Premature Stop | ENU | |
| sa25168 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37367 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37368 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Kazal domain | Kazal domain superfamily | MFS transporter superfamily | Organic anion transporter polypeptide |
|---|---|---|---|---|---|---|
| UniProtKB:F1Q5M5 | InterPro | 677 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slco2b1-201
(1)
|
Ensembl | 2,781 nt | ||
| mRNA |
slco2b1-204
(1)
|
Ensembl | 2,782 nt | ||
| mRNA |
slco2b1-206
(1)
|
Ensembl | 4,195 nt | ||
| mRNA |
slco2b1-207
(1)
|
Ensembl | 1,011 nt | ||
| ncRNA |
slco2b1-002
(1)
|
Ensembl | 1,029 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218M3 | ZFIN Curated Data | |
| Contained in | BAC | CH211-221P4 | ||
| Encodes | EST | fi40d02 | ||
| Encodes | EST | IMAGE:7158298 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:123236 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037678 (1) | 2781 nt | ||
| Genomic | GenBank:BX248108 (1) | 230610 nt | ||
| Polypeptide | UniProtKB:F1Q5M5 (1) | 677 aa |
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Cacialli, P., Mailhe, M.P., Wagner, I., Merkler, D., Golub, R., Bertrand, J.Y. (2022) Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. The EMBO journal. 41(19):e108536
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Wu, X., Xiong, F., Fang, H., Zhang, J., Chang, M. (2021) Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. Antibiotics (Basel, Switzerland). 10(7):
- Xiong, F., Cao, L., Wu, X.M., Chang, M.X. (2020) The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Developmental and comparative immunology. 116:103955
- Annunziato, K.M., Jantzen, C.E., Gronske, M.C., Cooper, K.R. (2019) Subtle morphometric, behavioral and gene expression effects in larval zebrafish exposed to PFHxA, PFHxS and 6:2 FTOH. Aquatic toxicology (Amsterdam, Netherlands). 208:126-137
- Lu, X., Tian, J., Wen, H., Jiang, M., Liu, W., Wu, F., Yu, L., Zhong, S. (2019) Microcystin-LR-regulated transcriptome dynamics in ZFL cells. Aquatic toxicology (Amsterdam, Netherlands). 212:222-232
- Wei, H., Wang, S., Xu, E.G., Liu, J., Li, X., Wang, Z. (2019) Synergistic toxicity of microcystin-LR and Cu to zebrafish (Danio rerio). The Science of the total environment. 713:136393
- Li, J., Chen, C., Zhang, T., Liu, W., Wang, L., Chen, Y., Wu, L., Hegazy, A.M., El-Sayed, A.F., Zhang, X. (2018) μEvaluation of microcystin-LR absorption using an in vivo intestine model and its effect on zebrafish intestine. Aquatic toxicology (Amsterdam, Netherlands). 206:186-194
- Oosterhof, N., Kuil, L.E., van der Linde, H.C., Burm, S.M., Berdowski, W., van Ijcken, W.F.J., van Swieten, J.C., Hol, E.M., Verheijen, M.H.G., van Ham, T.J. (2018) Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Reports. 24:1203-1217.e6
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