Gene
ihha
- ID
- ZDB-GENE-051010-1
- Name
- Indian hedgehog signaling molecule a
- Symbol
- ihha Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and patched binding activity. Acts upstream of or within several processes, including enteric nervous system development; intramembranous ossification; and swim bladder morphogenesis. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including caudal fin skeleton; cranium; digestive system; pneumatic duct; and swim bladder bud. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
acrocapitofemoral dysplasia | Alliance | Acrocapitofemoral dysplasia | 607778 |
brachydactyly type A1 | Alliance | Brachydactyly, type A1 | 112500 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Hedgehog, N-terminal signalling domain | Hedgehog protein | Hedgehog protein, Hint domain | Hedgehog Signaling | Hedgehog signalling/DD-peptidase zinc-binding domain superfamily | Hint domain C-terminal | Hint domain N-terminal | Hint domain superfamily | Intein N-terminal splicing region |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A3KNS3 | InterPro | 413 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
antisense |
ottdart00000059270
(1)
|
Ensembl | 1,666 nt | ||
mRNA |
ihha-201
(1)
|
Ensembl | 1,600 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(UAS:EGFP,UAS:ihha) |
|
| 1 | (2) |
1 - 1 of 1
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-67P4 | ZFIN Curated Data | |
Encodes | cDNA | MGC:162443 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001034993 (1) | 1616 nt | ||
Genomic | GenBank:BX942813 (2) | 96772 nt | ||
Polypeptide | UniProtKB:A3KNS3 (1) | 413 aa |
- Harboe, M., Kjaer-Sorensen, K., Füchtbauer, E.M., Fenton, R.A., Thomsen, J.S., Brüel, A., Oxvig, C. (2024) The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization. Scientific Reports. 14:2016120161
- Koosha, E., Brenna, C.T.A., Ashique, A.M., Jain, N., Ovens, K., Koike, T., Kitagawa, H., Eames, B.F. (2023) Proteoglycan inhibition of canonical BMP-dependent cartilage maturation delays endochondral ossification. Development (Cambridge, England). 151(2):
- Bergen, D.J.M., Tong, Q., Shukla, A., Newham, E., Zethof, J., Lundberg, M., Ryan, R., Youlten, S.E., Frysz, M., Croucher, P.I., Flik, G., Richardson, R.J., Kemp, J.P., Hammond, C.L., Metz, J.R. (2022) Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology. 20:21
- Iwasaki, M., Kawakami, K., Wada, H. (2022) Remodeling of the hyomandibular skeleton and facial nerve positioning during embryonic and postembryonic development of teleost fish. Developmental Biology. 489:134-145
- Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152
- Hawkins, M.B., Henke, K., Harris, M.P. (2021) Latent developmental potential to form limb-like skeletal structures in zebrafish. Cell. 184(4):899-911.e13
- Hoyle, D.J., Dranow, D.B., Schilling, T.F. (2021) Pthlha and mechanical force control early patterning of growth zones in the zebrafish craniofacial skeleton. Development (Cambridge, England). 149(2):
- Anderson, R.A., Schwalbach, K.T., Mui, S.R., LeClair, E.E., Topczewska, J.M., Topczewski, J. (2020) Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Disease models & mechanisms. 13(6):
- Wu, Y., Xu, Z., Xu, X., Fan, L., Jiang, X. (2020) Exposure to Metalaxyl Disturbs the Skeletal Development of Zebrafish Embryos. Bulletin of environmental contamination and toxicology. 104(4):432-437
- D'Agati, G., Cabello, E.M., Frontzek, K., Rushing, E.J., Klemm, R., Robinson, M.D., White, R.M., Mosimann, C., Burger, A. (2019) Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish. Disease models & mechanisms. 12(7):
1 - 10 of 51
Show