Gene

ihha

ID
ZDB-GENE-051010-1
Name
Indian hedgehog signaling molecule a
Symbol
ihha Nomenclature History
Previous Names
  • hh[a] (1)
  • hha
  • qhh (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable calcium ion binding activity and patched binding activity. Acts upstream of or within several processes, including enteric nervous system development; intramembranous ossification; and swim bladder morphogenesis. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including caudal fin skeleton; cranium; digestive system; pneumatic duct; and swim bladder bud. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
21 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hu2131Allele with one point mutationUnknownPremature StopENU
sa30645Allele with one point mutationUnknownPremature StopENU
sa34554Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-ihhaN/A (4)
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Human Disease
Associated With ihha Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acrocapitofemoral dysplasia Alliance Acrocapitofemoral dysplasia 607778
brachydactyly type A1 Alliance Brachydactyly, type A1 112500
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Associated With ihha Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000320 Hedgehog, N-terminal signalling domain
Domain IPR001767 Hedgehog protein, Hint domain
Domain IPR003586 Hint domain C-terminal
Domain IPR003587 Hint domain N-terminal
Family IPR001657 Hedgehog protein
1 - 5 of 9 Show all
Domain Details Per Protein
Protein Additional Resources Length Hedgehog, N-terminal signalling domain Hedgehog protein Hedgehog protein, Hint domain Hedgehog Signaling Hedgehog signalling/DD-peptidase zinc-binding domain superfamily Hint domain C-terminal Hint domain N-terminal Hint domain superfamily Intein N-terminal splicing region
UniProtKB:A3KNS3 InterPro 413
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 9
Type Name Annotation Method Has Havana Data Length (nt) Analysis
antisense ottdart00000059270 (1) Ensembl 1,666 nt
mRNA ihha-201 (1) Ensembl 1,600 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(UAS:EGFP,UAS:ihha)
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-67P4ZFIN Curated Data
EncodescDNAMGC:162443ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanIHH2
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseIhh1
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 51
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