Gene
rsad2
- ID
- ZDB-GENE-050913-129
- Name
- radical S-adenosyl methionine domain containing 2
- Symbol
- rsad2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable 4 iron, 4 sulfur cluster binding activity. Acts upstream of or within defense response to virus and inflammatory response to wounding. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and mitochondrion. Is expressed in several structures, including blood; brain; digestive system; mucus secreting cell; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in respiratory syncytial virus infectious disease. Orthologous to human RSAD2 (radical S-adenosyl methionine domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shanaka et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa13259 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa13885 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa19183 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
zf4050 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR006638 | Elp3/MiaA/NifB-like, radical SAM core domain |
Domain | IPR007197 | Radical SAM |
Family | IPR026372 | S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 |
Family | IPR051196 | RSAD2 and Viperin antiviral |
Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
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Domain Details Per Protein
Protein | Additional Resources | Length | Aldolase-type TIM barrel | Elp3/MiaA/NifB-like, radical SAM core domain | Radical SAM | RSAD2 and Viperin antiviral | S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 |
---|---|---|---|---|---|---|---|
UniProtKB:Q5RH95 | InterPro | 359 | |||||
UniProtKB:B2GP21 | InterPro | 359 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-276E8 | ||
Encodes | cDNA | MGC:112342 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191354 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001025556 (1) | 1646 nt | ||
Genomic | GenBank:BX571665 (2) | 166885 nt | ||
Polypeptide | UniProtKB:B2GP21 (1) | 359 aa |
- Ter Horst, S., Siekierska, A., De Meulemeester, A.S., Cuvry, A., Cools, L., Neyts, J., de Witte, P., Rocha-Pereira, J. (2025) The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent. Viruses. 17:
- Martínez-López, N., Pereiro, P., Saco, A., Lama, R., Figueras, A., Novoa, B. (2024) Characterization of a fish-specific Immunoglobulin-like domain-containing protein (Igldcp) in zebrafish (Danio rerio) induced after nodavirus infection. Developmental and comparative immunology. 162:105285
- Sow, A.A., Jamadagni, P., Scaturro, P., Patten, S.A., Chatel-Chaix, L. (2024) A zebrafish-based in vivo model of Zika virus infection unveils alterations of the glutamatergic neuronal development and NS4A as a key viral determinant of neuropathogenesis. PLoS pathogens. 20:e1012756e1012756
- Ding, C., Du, M., Xiong, Z., Wang, X., Li, H., He, E., Li, H., Dang, Y., Lu, Q., Li, S., Xiao, R., Xu, Z., Jing, L., Deng, L., Wang, X., Geng, M., Xie, Z., Zhang, A. (2023) Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth. Chemical science. 14:595659645956-5964
- Hong, Y., Hu, C.B., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2023) Essential role of an ERV-derived Env38 protein in adaptive humoral immunity against an exogenous SVCV infection in a zebrafish model. PLoS pathogens. 19:e1011222e1011222
- Li, Y.L., Gong, X.Y., Qu, Z.L., Zhao, X., Dan, C., Sun, H.Y., An, L.L., Gui, J.F., Zhang, Y.B. (2023) Zebrafish HERC7c Acts as an Inhibitor of Fish IFN Response. International Journal of Molecular Sciences. 24(5):
- Shanaka, K.A.S.N., Jung, S., Madushani, K.P., Kim, M.J., Lee, J. (2023) Viperin mutation is linked to immunity, immune cell dynamics, and metabolic alteration during VHSV infection in zebrafish. Frontiers in immunology. 14:13277491327749
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- Chen, S.N., Gan, Z., Hou, J., Yang, Y.C., Huang, L., Huang, B., Wang, S., Nie, P. (2022) Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Nature communications. 13:999
- Gong, X.Y., Zhang, Q.M., Zhao, X., Li, Y.L., Qu, Z.L., Li, Z., Dan, C., Gui, J.F., Zhang, Y.B. (2022) LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response. iScience. 25:104821
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