Gene

rsad2

ID
ZDB-GENE-050913-129
Name
radical S-adenosyl methionine domain containing 2
Symbol
rsad2 Nomenclature History
Previous Names
  • si:ch211-276e8.2
  • vig1 (1)
  • viperin (1)
  • zgc:112342
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Acts upstream of or within defense response to virus and inflammatory response to wounding. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and mitochondrion. Is expressed in several structures, including blood; brain; digestive system; mucus secreting cell; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in respiratory syncytial virus infectious disease. Orthologous to human RSAD2 (radical S-adenosyl methionine domain containing 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Shanaka et al., 2023
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa13259Allele with one point mutationUnknownPremature StopENU
sa13885Allele with one point mutationUnknownSplice SiteENU
sa19183Allele with one point mutationUnknownPremature StopENU
zf4050Allele with one deletionExon 1Frameshift, Premature StopCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-rsad2 (2)
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Human Disease
Associated With rsad2 Human Ortholog
No data available
Associated With rsad2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain
Domain IPR007197 Radical SAM
Family IPR026372 S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
Family IPR051196 RSAD2 and Viperin antiviral
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
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Domain Details Per Protein
Protein Additional Resources Length Aldolase-type TIM barrel Elp3/MiaA/NifB-like, radical SAM core domain Radical SAM RSAD2 and Viperin antiviral S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
UniProtKB:Q5RH95 InterPro 359
UniProtKB:B2GP21 InterPro 359
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA rsad2-201 (1) Ensembl 1,623 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-276E8
EncodescDNAMGC:112342ZFIN Curated Data
EncodescDNAMGC:191354ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanRSAD22
Amino acid sequence comparison (3)
Conserved genome location (synteny) (1)
MouseRsad212
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 51
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