ZFIN is now using GRCz12tu for Genomic Data
Gene
comta
- ID
- ZDB-GENE-050913-117
- Name
- catechol-O-methyltransferase a
- Symbol
- comta Nomenclature History
- Previous Names
-
- zgc:114157 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables catechol O-methyltransferase activity. Predicted to be involved in catecholamine catabolic process; developmental process; and dopamine metabolic process. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; male organism; nervous system; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Catechol-O-methyltransferase activity, variation in] | 621296 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Catechol O-methyltransferase, eukaryotic | Class I-like SAM-dependent O-methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|
| UniProtKB:F4ZGF2 | InterPro | 256 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers