Gene
pygo2
- ID
- ZDB-GENE-050809-108
- Name
- pygopus homolog 2 (Drosophila)
- Symbol
- pygo2 Nomenclature History
- Previous Names
-
- fc56f02
- wu:fc46c10
- wu:fc56f02
- wu:fi37d10
- wu:fj66f08
- wu:fy30b05
- zgc:111854
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis; heart development; and regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Shull et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pygo2 | (2) | |
| MO1-pygo2 | N/A | Huang et al., 2013 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wnt Signal Transduction Protein | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1L8T6 | InterPro | 571 | ||||||
| UniProtKB:A0A8M2B671 | InterPro | 556 | ||||||
| UniProtKB:A0AB13A9K6 | InterPro | 556 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-204A24 | ZFIN Curated Data | |
| Encodes | EST | fc46c10 | ZFIN Curated Data | |
| Encodes | EST | fc56f02 | ||
| Encodes | EST | fi37d10 | ZFIN Curated Data | |
| Encodes | EST | fj66f08 | ZFIN Curated Data | |
| Encodes | EST | fy30b05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173911 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:111854 | ZFIN Curated Data |
1 - 8 of 8
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001033111 (1) | 3739 nt | ||
| Genomic | GenBank:CR628394 (2) | 242800 nt | ||
| Polypeptide | UniProtKB:Q1L8T6 (1) | 571 aa |
No data available
- Shull, L.C., Lencer, E.S., Kim, H.M., Goyama, S., Kurokawa, M., Costello, J.C., Jones, K., Artinger, K.B. (2022) PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation. Development (Cambridge, England). 149(4):
- Doll, L., Aghaallaei, N., Dick, A.M., Welte, K., Skokowa, J., Bajoghli, B. (2020) A zebrafish model for HAX1-associated congenital neutropenia. Haematologica. 106(5):1311-1320
- Cantù, C., Felker, A., Zimmerli, D., Prummel, K.D., Cabello, E.M., Chiavacci, E., Méndez-Acevedo, K.M., Kirchgeorg, L., Burger, S., Ripoll, J., Valenta, T., Hausmann, G., Vilain, N., Aguet, M., Burger, A., Panáková, D., Basler, K., Mosimann, C. (2018) Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.. Genes & Development. 32(21-22):1443-1458
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 6 of 6
Show