Gene
slc8a1a
- ID
- ZDB-GENE-050809-1
- Name
- solute carrier family 8 member 1a
- Symbol
- slc8a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables calcium:sodium antiporter activity. Acts upstream of or within several processes, including enteric nervous system development; intracellular calcium ion homeostasis; and sarcomere organization. Predicted to be located in membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Is expressed in anterior lateral plate mesoderm; heart primordium; and pericardial region. Used to study atrial fibrillation. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
m116 | unknown | Unknown | Unknown | ENU | |
m139 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
m158 | unknown | Unknown | Unknown | ENU | |
m276 | unknown | Unknown | Unknown | ENU | |
m736 | unknown | Unknown | Unknown | ENU | |
sa35118 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
tc318d | Allele with one point mutation | Unknown | Premature Stop | ENU | |
te381b | unknown | Unknown | Unknown | ENU | |
zf3602 | Allele with one point mutation | Unknown | Missense | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-slc8a1a | Chu et al., 2020 | |
CRISPR2-slc8a1a | Kuil et al., 2021 | |
MO1-slc8a1a | N/A | (2) |
MO2-slc8a1a | N/A | (6) |
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Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
atrial fibrillation | slc8a1atc318d/tc318d; twu34Tg | standard conditions | Sander et al., 2021 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
Domain | IPR004837 | Sodium/calcium exchanger membrane region |
Domain | IPR032452 | Sodium/calcium exchanger domain, C-terminal extension |
Family | IPR004836 | Sodium/calcium exchanger protein |
Family | IPR051171 | Calcium/Cation Antiporter |
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Domain Details Per Protein
Protein | Additional Resources | Length | Calcium/Cation Antiporter | CalX-like domain superfamily | Na-Ca exchanger/integrin-beta4 | NCX, central ion-binding domain superfamily | Sodium/calcium exchanger domain, C-terminal extension | Sodium/calcium exchanger membrane region | Sodium/calcium exchanger protein |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1R4F4 | InterPro | 969 | |||||||
UniProtKB:A0A286YBI0 | InterPro | 933 | |||||||
UniProtKB:Q32SG8 | InterPro | 974 | |||||||
UniProtKB:A0A8M9QLM2 | InterPro | 338 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
slc8a1a-201
(1)
|
Ensembl | 2,892 nt | ||
mRNA |
slc8a1a-202
(1)
|
Ensembl | 3,647 nt | ||
mRNA |
slc8a1a-203
(1)
|
Ensembl | 2,925 nt | ||
mRNA |
slc8a1a-204
(1)
|
Ensembl | 3,289 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-28O14 | ZFIN Curated Data | |
Contained in | BAC | DKEY-218G22 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001037102 (1) | 2925 nt | ||
Genomic | GenBank:CR556713 (1) | 229692 nt | ||
Polypeptide | UniProtKB:Q32SG8 (1) | 974 aa |
- Jia, B.Z., Qi, Y., Wong-Campos, J.D., Megason, S.G., Cohen, A.E. (2023) A bioelectrical phase transition patterns the first vertebrate heartbeats. Nature. 622(7981):149-155
- Akerberg, A.A., Trembley, M., Butty, V., Schwertner, A., Zhao, L., Beerens, M., Liu, X., Mahamdeh, M., Yuan, S., Boyer, L., MacRae, C., Nguyen, C., Pu, W.T., Burns, C.E., Burns, C.G. (2022) RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circulation research. 131(12):980-1000
- Zhou, C., Zhao, W., Zhang, S., Ma, J., Sultan, Y., Li, X. (2022) High-throughput transcriptome sequencing reveals the key stages of cardiovascular development in zebrafish embryos. BMC Genomics. 23:587
- Zhu, L., Wang, C., Jiang, H., Zhang, L., Mao, L., Zhang, Y., Qi, S., Liu, X. (2022) Quizalofop-P-ethyl induced developmental toxicity and cardiotoxicity in early life stage of zebrafish (Danio rerio). Ecotoxicology and environmental safety. 238:113596
- Hu, M., Liu, P., Lu, S., Wang, Z., Lyu, Z., Liu, H., Sun, Y., Liu, F., Tian, J. (2021) Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish. Chinese Medicine. 16:119
- Kuil, L.E., MacKenzie, K.C., Tang, C.S., Windster, J.D., Le, T.L., Karim, A., de Graaf, B.M., van der Helm, R., van Bever, Y., Sloots, C.E.J., Meeussen, C., Tibboel, D., de Klein, A., Wijnen, R.M.H., Amiel, J., Lyonnet, S., Garcia-Barcelo, M.M., Tam, P.K.H., Alves, M.M., Brooks, A.S., Hofstra, R.M.W., Brosens, E. (2021) Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. PLoS Genetics. 17:e1009698
- Sander, P., Feng, M., Schweitzer, M.K., Wilting, F., Gutenthaler, S.M., Arduino, D.M., Fischbach, S., Dreizehnter, L., Moretti, A., Gudermann, T., Perocchi, F., Schredelseker, J. (2021) Approved drugs ezetimibe and disulfiram enhance mitochondrial Ca2+ uptake and suppress cardiac arrhythmogenesis. British journal of pharmacology. 178(22):4518-4532
- Shimizu, H., Huber, S., Langenbacher, A.D., Crisman, L., Huang, J., Wang, K., Wilting, F., Gudermann, T., Schredelseker, J., Chen, J.N. (2021) Glutamate 73 Promotes Anti-arrhythmic Effects of Voltage-Dependent Anion Channel Through Regulation of Mitochondrial Ca2+ Uptake. Frontiers in Physiology. 12:724828
- Chu, L., Yin, H., Gao, L., Gao, L., Xia, Y., Zhang, C., Chen, Y., Liu, T., Huang, J., Boheler, K.R., Zhou, Y., Yang, H.T. (2020) Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish. Science China. Life sciences. 64(2):255-268
- Han, C.R., Wang, H., Hoffmann, V., Zerfas, P., Kruhlak, M., Cheng, S.Y. (2020) Thyroid hormone receptor α mutations cause heart defects in zebrafish. Thyroid : official journal of the American Thyroid Association. 31(2):315-326
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