Gene
dpysl3
- ID
- ZDB-GENE-050720-2
- Name
- dihydropyrimidinase like 3
- Symbol
- dpysl3 Nomenclature History
- Previous Names
-
- CRMP-4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Acts upstream of or within axonogenesis; forebrain development; and regulation of axonogenesis. Predicted to be located in cytoplasm and growth cone. Predicted to be active in cytosol. Is expressed in nervous system; neural plate; spinal cord neural tube; and trigeminal placode. Orthologous to human DPYSL3 (dihydropyrimidinase like 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022039Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa37377 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| wa41 | Allele with one delins | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dpysl3 | Guo et al., 2022 | |
| MO1-dpysl3 | N/A | (5) |
| MO2-dpysl3 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006680 | Amidohydrolase-related |
| Family | IPR011778 | Hydantoinase/dihydropyrimidinase |
| Family | IPR050378 | Metallo-dependent Hydrolases Superfamily |
| Homologous_superfamily | IPR011059 | Metal-dependent hydrolase, composite domain superfamily |
| Homologous_superfamily | IPR032466 | Metal-dependent hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Amidohydrolase-related | Hydantoinase/dihydropyrimidinase | Metal-dependent hydrolase | Metal-dependent hydrolase, composite domain superfamily | Metallo-dependent Hydrolases Superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q52PJ5 | InterPro | 567 | |||||
| UniProtKB:A0AB32TEV0 | InterPro | 661 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dpysl3-201
(1)
|
Ensembl | 5,023 nt | ||
| mRNA |
dpysl3-202
(1)
|
Ensembl | 689 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-280B7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193829 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193863 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020512 (1) | 5026 nt | ||
| Genomic | GenBank:CU462980 (2) | 116857 nt | ||
| Polypeptide | UniProtKB:A0AB32TEV0 (1) | 661 aa |
- Guo, Y., Oliveros, C.F., Ohshima, T. (2022) CRMP2 and CRMP4 are required for the formation of commissural tracts in the developing zebrafish forebrain. Developmental Neurobiology. 82(6):533-544
- Liu, Z.Z., Zhu, J., Wang, C.L., Wang, X., Han, Y.Y., Liu, L.Y., Xu, H.A. (2018) CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons. Neural Plasticity. 2018:8791304
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lagman, D., Franzén, I.E., Eggert, J., Larhammar, D., Abalo, X.M. (2016) Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. BMC Evolutionary Biology. 16:124
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Morimura, R., Nozawa, K., Tanaka, H., and Ohshima, T. (2013) Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord. Developmental Neurobiology. 73(12):911-20
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Tanaka, H., Morimura, R., and Ohshima, T. (2012) Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish. Developmental Biology. 370(2):223-236
- Huang, Q.Y., Huang, L., and Huang, H.Q. (2011) Proteomic analysis of methyl parathion-responsive proteins in zebrafish (Danio rerio) brain. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 153(1):67-74
- Tanaka, H., Nojima, Y., Shoji, W., Sato, M., Nakayama, R., Ohshima, T., and Okamoto, H. (2011) Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(1):9-22
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