Gene
cyp26c1
- ID
- ZDB-GENE-050714-2
- Name
- cytochrome P450, family 26, subfamily C, polypeptide 1
- Symbol
- cyp26c1 Nomenclature History
- Previous Names
-
- cyp26b1l
- cyp26d1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable monooxygenase activity. Acts upstream of or within several processes, including circulatory system development; retinoic acid metabolic process; and rhombomere 4 morphogenesis. Is expressed in several structures, including brain; eye; hindbrain neural keel; optic cup; and pleuroperitoneal region. Orthologous to human CYP26C1 (cytochrome P450 family 26 subfamily C member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Montalbano et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
tpl24Gt | Transgenic insertion | Unknown | Unknown | DNA |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-cyp26c1 | Addison et al., 2018 | |
CRISPR2-cyp26c1 | Addison et al., 2018 | |
MO1-cyp26c1 | N/A | (7) |
MO2-cyp26c1 | N/A | (4) |
MO3-cyp26c1 | N/A | White et al., 2007 |
MO4-cyp26c1 | N/A | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Focal facial dermal dysplasia 4 | 614974 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group IV | Cytochrome P450 superfamily |
---|---|---|---|---|---|---|
UniProtKB:A1L1M2 | InterPro | 554 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
antisense |
ottdart00000055385
(1)
|
Ensembl | 497 nt | ||
mRNA |
cyp26c1-201
(1)
|
Ensembl | 4,032 nt | ||
mRNA |
cyp26c1-202
(1)
|
Ensembl | 1,689 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-71B20 | ZFIN Curated Data | |
Encodes | cDNA | MGC:158120 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001029951 (1) | 4034 nt | ||
Genomic | GenBank:CU571091 (2) | 75771 nt | ||
Polypeptide | UniProtKB:A1L1M2 (1) | 554 aa |
- Chen, B., Ran, Q., Chen, X., Deng, Z., Zhou, R., Zhang, Y., Liu, M., Li, B., Huang, S., Wang, P., Huang, S. (2024) Cxcr4a regulates heart progenitor development and cardiac rhythm in zebrafish. Biochemistry and biophysics reports. 39:101782101782
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Ulhaq, Z.S., Okamoto, K., Ogino, Y., Fai Tse, W.K. (2023) Dysregulation of spliceosomes complex induces retinitis pigmentosa-like characteristics in sf3b4-depleted zebrafish. The American journal of pathology. 193(9):1223-1233
- Feng, G., Sun, Y. (2022) The Polycomb group gene rnf2 is essential for central and enteric neural system development in zebrafish. Frontiers in neuroscience. 16:960149
- Song, M., Yuan, X., Racioppi, C., Leslie, M., Stutt, N., Aleksandrova, A., Christiaen, L., Wilson, M.D., Scott, I.C. (2022) GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. Science advances. 8:eabg0834
- Wei, G., Zhang, X., Cai, C., Sheng, J., Xu, M., Wang, C., Gu, Q., Guo, C., Chen, F., Liu, D., Qian, F. (2022) Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway. Frontiers in Cellular Neuroscience. 16:840143
- Yu, W.X., Li, Y.K., Xu, M.F., Xu, C.J., Chen, J., Wei, Y.L., She, Z.Y. (2022) Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development. Cell death discovery. 8:490490
- Hoffmann, S., Roeth, R., Diebold, S., Gogel, J., Hassel, D., Just, S., Rappold, G.A. (2021) Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes. Frontiers in genetics. 12:688808
- Song, Y.C., Dohn, T.E., Rydeen, A.B., Nechiporuk, A.V., Waxman, J.S. (2019) HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development. PLoS Genetics. 15:e1008165
- Wang, H., Holland, P.W.H., Takahashi, T. (2019) Gene profiling of head mesoderm in early zebrafish development: insights into the evolution of cranial mesoderm. EvoDevo. 10:14
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