Gene
uncx4.1
- ID
- ZDB-GENE-050714-1
- Name
- Unc4.1 homeobox (C. elegans)
- Symbol
- uncx4.1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within cell differentiation; nervous system development; and regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including brain; corpuscles of Stannius; hindbrain neural keel; segmental plate; and shield. Orthologous to human UNCX (UNC homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-uncx4.1 | Sun et al., 2019 | |
MO1-uncx4.1 | N/A | Nittoli et al., 2019 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain |
---|---|---|---|---|---|
UniProtKB:Q50D79 | InterPro | 470 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
uncx4.1-201
(1)
|
Ensembl | 1,902 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(uncx4.1:GFP) |
|
| 1 | Zebrafish Nomenclature Committee |
1 - 1 of 1
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-51I10 | ZFIN Curated Data | |
Contained in | BAC | CH211-57E21 | ZFIN Curated Data | |
Encodes | cDNA | MGC:136321 | ZFIN Curated Data |
1 - 3 of 3
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001020780 (1) | 1958 nt | ||
Genomic | GenBank:AL954703 | 184073 nt | ||
Polypeptide | UniProtKB:Q50D79 (1) | 470 aa |
No data available
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Dogra, D., Reischauer, S., Mokalled, M.H. (2022) Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish. Cell Reports. 41:111705111705
- Simsek, M.F., Chandel, A.S., Saparov, D., Zinani, O.Q.H., Clason, N., Özbudak, E.M. (2022) Periodic inhibition of Erk activity drives sequential somite segmentation. Nature. 613(7942):153-159
- Ban, H., Yokota, D., Otosaka, S., Kikuchi, M., Kinoshita, H., Fujino, Y., Yabe, T., Ovara, H., Izuka, A., Akama, K., Yamasu, K., Takada, S., Kawamura, A. (2019) Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation. Development (Cambridge, England). 146(18):
- Nittoli, V., Fortunato, A.E., Fasano, G., Coppola, U., Gentile, A., Maiella, S., Langellotto, F., Porreca, I., De Paolo, R., Marino, R., Fiengo, M., Donizetti, A., Aniello, F., Kondo, T., Ristoratore, F., Canzoniero, L.M.T., Duboule, D., Wilson, S.W., Sordino, P. (2019) Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Gene X. 2:100011
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Fujino, Y., Yamada, K., Sugaya, C., Ooka, Y., Ovara, H., Ban, H., Akama, K., Otosaka, S., Kinoshita, H., Yamasu, K., Mishima, Y., Kawamura, A. (2018) Deadenylation by the CCR4-NOT complex contributes to the turnover of hairy-related mRNAs in the zebrafish segmentation clock. FEBS letters. 592(20):3388-3398
- Kinoshita, H., Ohgane, N., Fujino, Y., Yabe, T., Ovara, H., Yokota, D., Izuka, A., Kage, D., Yamasu, K., Takada, S., Kawamura, A. (2018) Functional roles of the Ripply-mediated suppression of segmentation gene expression at the anterior presomitic mesoderm in zebrafish. Mechanisms of Development. 152:21-31
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Guo, L., Yamashita, H., Kou, I., Takimoto, A., Meguro-Horike, M., Horike, S.I., Sakuma, T., Miura, S., Adachi, T., Yamamoto, T., Ikegawa, S., Hiraki, Y., Shukunami, C. (2016) Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation. PLoS Genetics. 12:e1005802
1 - 10 of 24
Show