Gene
spp1
- ID
- ZDB-GENE-050706-97
- Name
- secreted phosphoprotein 1
- Symbol
- spp1 Nomenclature History
- Previous Names
-
- osteopontin (1)
- zgc:111821
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Acts upstream of or within bone development. Is expressed in several structures, including central nervous system; cranium; fin; heart; and osteoblast. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 55 figures from 44 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Venkatesh et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-spp1 | Venkatesh et al., 2014 | |
| CRISPR2-spp1 | Venkatesh et al., 2014 | |
| CRISPR3-spp1 | (2) | |
| CRISPR4-spp1 | Nie et al., 2022 | |
| MO1-spp1 | N/A | Venkatesh et al., 2014 |
| MO2-spp1 | N/A | Venkatesh et al., 2014 |
| TALEN1-spp1 | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR002038 | Osteopontin |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Osteopontin |
|---|---|---|---|
| UniProtKB:Q6IVB9 | InterPro | 305 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(spp1:mCherry) |
|
| 1 | (2) | |
| Tg(spp1:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-272D15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111821 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002308 (1) | 1482 nt | ||
| Genomic | GenBank:CR925756 (2) | 107798 nt | ||
| Polypeptide | UniProtKB:Q6IVB9 (1) | 305 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SPP1 | 4 | Amino acid sequence comparison (1) |
- Gjorcheska, S., Paudel, S., McLeod, S., Paulding, D., Snape, L., Sosa, K.C., Duan, C., Kelsh, R., Barske, L. (2025) Sox10 is required for systemic initiation of bone mineralization. Development (Cambridge, England). 152(2):
- Liu, B., Wang, P., Lv, X. (2025) Phytol-mixed micelles alleviate dexamethasone-induced osteoporosis in zebrafish: Activation of the MMP3-OPN-MAPK pathway-mediating bone remodeling. Open life sciences. 20:2022101520221015
- Cotti, S., Di Biagio, C., Huysseune, A., Koppe, W., Forlino, A., Witten, P.E. (2024) Matrix first, minerals later: fine-tuned dietary phosphate increases bone formation in zebrafish. JBMR plus. 8:ziae081ziae081
- da Silva, A.R., Gunawan, F., Boezio, G.L.M., Faure, E., Théron, A., Avierinos, J.F., Lim, S., Jha, S.G., Ramadass, R., Guenther, S., Looso, M., Zaffran, S., Juan, T., Stainier, D.Y.R. (2024) egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. Science advances. 10:eadl0633
- Jiang, Z., Deng, L., Xiang, G., Xu, X., Wang, Y. (2024) A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression. Antioxidants (Basel, Switzerland). 13(4):
- Kabir, A., B, M., A, N., Selvaraj, V., Sudhakar, S. (2024) Protein Nano Coop Complexes Promote Fracture Healing and Bone Regeneration in a Zebrafish Osteoporosis Model. Biomacromolecules. 25(11):7237-7248
- Raman, R., Antony, M., Nivelle, R., Lavergne, A., Zappia, J., Guerrero-Limón, G., Caetano da Silva, C., Kumari, P., Sojan, J.M., Degueldre, C., Bahri, M.A., Ostertag, A., Collet, C., Cohen-Solal, M., Plenevaux, A., Henrotin, Y., Renn, J., Muller, M. (2024) The Osteoblast Transcriptome in Developing Zebrafish Reveals Key Roles for Extracellular Matrix Proteins Col10a1a and Fbln1 in Skeletal Development and Homeostasis. Biomolecules. 14(2):
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Arthi, B., Chellathai, D. (2023) Effects of vasicine in neuroinflammatory zebrafish model. Bioinformation. 19:595604595-604
- Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783
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