Gene
gstp1.1
- ID
- ZDB-GENE-050601-1
- Name
- glutathione S-transferase pi 1.1
- Symbol
- gstp1.1 Nomenclature History
- Previous Names
-
- gstp2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables glutathione transferase activity. Acts upstream of or within response to toxic substance. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytosol. Is expressed in brain; gill; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-gstp1.1 | O'Brown et al., 2023 | |
CRISPR2-gstp1.1 | O'Brown et al., 2023 | |
CRISPR3-gstp1.1 | O'Brown et al., 2023 | |
MO1-gstp1.1 | N/A | Garner et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR004045 | Glutathione S-transferase, N-terminal |
Domain | IPR004046 | Glutathione S-transferase, C-terminal |
Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
Family | IPR003082 | Glutathione S-transferase, Pi class |
Family | IPR050213 | Glutathione S-transferase superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Glutathione S-transferase, C-terminal | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione S-transferase, N-terminal | Glutathione S-transferase, Pi class | Glutathione S-transferase superfamily | Thioredoxin-like superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q50LC6 | InterPro | 208 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-370D1 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195083 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195092 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001020513 (1) | 714 nt | ||
Genomic | GenBank:FP102983 (1) | 91094 nt | ||
Polypeptide | UniProtKB:Q50LC6 (1) | 208 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | GSTP1 | 11 | Phylogenetic tree (2) |
- O'Brown, N.M., Patel, N.B., Hartmann, U., Klein, A.M., Gu, C., Megason, S.G. (2023) The secreted neuronal signal spock1 promotes blood-brain barrier development. Developmental Cell. 58(17):1534-1547.e6
- Xu, Y., Peng, T., Zhou, Q., Zhu, J., Liao, G., Zou, F., Meng, X. (2023) Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 266:109550
- Gao, X.M., Li, B., Wang, M.Y., Liu, H.D., Tang, L.P., Wang, F., Yan, D.M., Han, X.Y., Xu, L.X. (2022) Transcriptome analysis of developing zebrafish (Danio rerio) embryo following exposure to Gaudichaudione H reveals teratogenicity and cardiovascular defects caused by abnormal iron metabolism. Chemico-biological interactions. 361:109968
- Hari Deva Muthu, B., Manjunathan, T., Guru, A., Kumar, R.S., Rajakrishnan, R., Kuppusamy, P., Juliet, A., Gopinath, P., Arockiaraj, J. (2022) Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle. Life sciences. 298:120507
- Haridevamuthu, B., Manjunathan, T., Guru, A., Ranjith Wilson Alphonse, C., Boopathi, S., Murugan, R., Gatasheh, M.K., Atef Hatamleh, A., Juliet, A., Gopinath, P., Arockiaraj, J. (2022) Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae. Brain research. 1788:147941
- Kitipaspallop, W., Sillapaprayoon, S., Phuwapraisirisan, P., Kim, W.K., Chanchao, C., Pimtong, W. (2022) Developmental effects of sesamolin on zebrafish (Danio rerio) embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 256:109319
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Van Hall-Beauvais, A., Poganik, J.R., Huang, K.T., Parvez, S., Zhao, Y., Lin, H.Y., Liu, X., Long, M.J.C., Aye, Y. (2022) Z-REX uncovers a bifurcation in function of Keap1 paralogs. eLIFE. 11:
- Huang, Y., Xia, Y., Tao, Y., Jin, H., Ji, C., Aniagu, S., Chen, T., Jiang, Y. (2021) Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. Toxicology. 452:152697
- Lovin, L.M., Kim, S., Taylor, R.B., Scarlett, K.R., Langan, L.M., Chambliss, C.K., Chatterjee, S., Scott, J.T., Brooks, B.W. (2021) Differential influences of (±) anatoxin-a on photolocomotor behavior and gene transcription in larval zebrafish and fathead minnows. Environmental sciences Europe. 33(1):
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