Gene
lats1
- ID
- ZDB-GENE-050523-2
- Name
- large tumor suppressor kinase 1
- Symbol
- lats1 Nomenclature History
- Previous Names
-
- si:dkey-181i3.5
- wu:fc19a11
- zgc:123219
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within convergent extension involved in gastrulation. Predicted to be located in centrosome. Is expressed in several structures, including head; heart; liver; pectoral fin; and pleuroperitoneal region. Used to study autosomal dominant polycystic kidney disease. Orthologous to human LATS1 (large tumor suppressor kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chen et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Chen et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021389Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| ncv107 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| sa36934 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf2211 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lats1 | (2) | |
| CRISPR2-lats1 | (2) | |
| CRISPR3-lats1 | (2) | |
| CRISPR4-lats1 | (2) | |
| CRISPR5-lats1 | (2) | |
| CRISPR6-lats1 | (2) | |
| CRISPR7-lats1 | (2) | |
| CRISPR8-lats1 | (2) | |
| CRISPR9-lats1 | (2) | |
| CRISPR10-lats1 | (2) |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal dominant polycystic kidney disease | lats1zf2211/zf2211 | standard conditions | Xu et al., 2018 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR049761 | Serine/threonine-protein kinase , Mob-binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase , Mob-binding domain | Serine/threonine-protein kinases, AGC |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A9JTE1 | InterPro | 632 | |||||||
| UniProtKB:Q58FB8 | InterPro | 1068 | |||||||
| UniProtKB:Q5RIL6 | InterPro | 1068 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-181I3 | ZFIN Curated Data | |
| Encodes | EST | fc19a11 | ||
| Encodes | cDNA | MGC:123219 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175000 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198071 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020510 (1) | 3207 nt | ||
| Genomic | GenBank:BX248418 (1) | 152757 nt | ||
| Polypeptide | UniProtKB:Q58FB8 (1) | 1068 aa |
- Li, M., Wang, R., Yan, T., Tao, X., Gao, S., Wang, Z., Chai, Y., Qiu, S., Chen, W. (2024) Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway. British journal of pharmacology. 182(4):1090-1106
- Lundin, V., Sugden, W.W., Theodore, L.N., Sousa, P.M., Han, A., Chou, S., Wrighton, P.J., Cox, A.G., Ingber, D.E., Goessling, W., Daley, G.Q., North, T.E. (2020) YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Developmental Cell. 52(4):446-460.e5
- Brandt, Z.J., North, P.N., Link, B.A. (2019) Somatic Mutations of lats2 Cause Peripheral Nerve Sheath Tumors in Zebrafish. Cells. 8(9)
- Fukui, H., Miyazaki, T., Chow, R.W., Ishikawa, H., Nakajima, H., Vermot, J., Mochizuki, N. (2018) Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish. eLIFE. 7
- Xu, D., Lv, J., He, L., Fu, L., Hu, R., Cao, Y., Mei, C. (2018) Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(8):4394-4407
- Nakajima, H., Yamamoto, K., Agarwala, S., Terai, K., Fukui, H., Fukuhara, S., Ando, K., Miyazaki, T., Yokota, Y., Schmelzer, E., Belting, H.G., Affolter, M., Lecaudey, V., Mochizuki, N. (2017) Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Developmental Cell. 40:523-536.e6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Fukui, H., Terai, K., Nakajima, H., Chiba, A., Fukuhara, S., Mochizuki, N. (2014) S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish. Developmental Cell. 31:128-136
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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