Gene
lats1
- ID
- ZDB-GENE-050523-2
- Name
- large tumor suppressor kinase 1
- Symbol
- lats1 Nomenclature History
- Previous Names
-
- si:dkey-181i3.5
- wu:fc19a11
- zgc:123219
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of with a negative effect on BMP signaling pathway. Acts upstream of or within convergent extension involved in gastrulation and secondary heart field specification. Predicted to be located in centrosome. Is expressed in several structures, including head; heart; liver; pectoral fin; and pleuroperitoneal region. Used to study autosomal dominant polycystic kidney disease. Orthologous to human LATS1 (large tumor suppressor kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chen et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Chen et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la021389Tg | Transgenic insertion | Unknown | Unknown | DNA | |
ncv107 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
sa36934 | Allele with one point mutation | Unknown | Splice Site | ENU | |
zf2211 | Allele with one delins | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-lats1 | (2) | |
CRISPR2-lats1 | (2) | |
CRISPR3-lats1 | (2) | |
CRISPR4-lats1 | (2) | |
CRISPR5-lats1 | (2) | |
CRISPR6-lats1 | (2) | |
CRISPR7-lats1 | (2) | |
CRISPR8-lats1 | (2) | |
CRISPR9-lats1 | (2) | |
CRISPR10-lats1 | (2) |
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Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
autosomal dominant polycystic kidney disease | lats1zf2211/zf2211 | standard conditions | Xu et al., 2018 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR000961 | AGC-kinase, C-terminal |
Domain | IPR049761 | Serine/threonine-protein kinase , Mob-binding domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | AGC-kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase , Mob-binding domain | Serine/threonine-protein kinases, AGC |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A9JTE1 | InterPro | 632 | |||||||
UniProtKB:Q58FB8 | InterPro | 1068 | |||||||
UniProtKB:Q5RIL6 | InterPro | 1068 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-181I3 | ZFIN Curated Data | |
Encodes | EST | fc19a11 | ||
Encodes | cDNA | MGC:123219 | ZFIN Curated Data | |
Encodes | cDNA | MGC:175000 | ZFIN Curated Data | |
Encodes | cDNA | MGC:198071 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001020510 (1) | 3207 nt | ||
Genomic | GenBank:BX248418 (1) | 152757 nt | ||
Polypeptide | UniProtKB:Q58FB8 (1) | 1068 aa |
- Li, M., Wang, R., Yan, T., Tao, X., Gao, S., Wang, Z., Chai, Y., Qiu, S., Chen, W. (2024) Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway. British journal of pharmacology. 182(4):1090-1106
- Lundin, V., Sugden, W.W., Theodore, L.N., Sousa, P.M., Han, A., Chou, S., Wrighton, P.J., Cox, A.G., Ingber, D.E., Goessling, W., Daley, G.Q., North, T.E. (2020) YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Developmental Cell. 52(4):446-460.e5
- Brandt, Z.J., North, P.N., Link, B.A. (2019) Somatic Mutations of lats2 Cause Peripheral Nerve Sheath Tumors in Zebrafish. Cells. 8(9)
- Fukui, H., Miyazaki, T., Chow, R.W., Ishikawa, H., Nakajima, H., Vermot, J., Mochizuki, N. (2018) Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish. eLIFE. 7
- Xu, D., Lv, J., He, L., Fu, L., Hu, R., Cao, Y., Mei, C. (2018) Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(8):4394-4407
- Nakajima, H., Yamamoto, K., Agarwala, S., Terai, K., Fukui, H., Fukuhara, S., Ando, K., Miyazaki, T., Yokota, Y., Schmelzer, E., Belting, H.G., Affolter, M., Lecaudey, V., Mochizuki, N. (2017) Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Developmental Cell. 40:523-536.e6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Fukui, H., Terai, K., Nakajima, H., Chiba, A., Fukuhara, S., Mochizuki, N. (2014) S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish. Developmental Cell. 31:128-136
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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