Gene
tdg.1
- ID
- ZDB-GENE-050522-44
- Name
- thymine DNA glycosylase, tandem duplicate 1
- Symbol
- tdg.1 Nomenclature History
- Previous Names
-
- tdg
- wu:fb44b11
- zgc:110622
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable pyrimidine-specific mismatch base pair DNA N-glycosylase activity and uracil DNA N-glycosylase activity. Predicted to be involved in base-excision repair, AP site formation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in retina. Orthologous to human TDG (thymine DNA glycosylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110622 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Manesia et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tdg.1 | N/A | Rai et al., 2010 |
| MO2-tdg.1 | N/A | Manesia et al., 2017 |
| MO3-tdg.1 | N/A | Manesia et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotes | Uracil DNA glycosylase family 2 | Uracil-DNA glycosylase-like | Uracil-DNA glycosylase-like domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q503G3 | InterPro | 441 | ||||
| UniProtKB:A0A8M2BA24 | InterPro | 404 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-68A17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-218L23 | ZFIN Curated Data | |
| Encodes | EST | fb44b11 | ||
| Encodes | cDNA | MGC:110622 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192973 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020751 (1) | 2732 nt | ||
| Genomic | GenBank:BX897714 (1) | 184435 nt | ||
| Polypeptide | UniProtKB:Q503G3 (1) | 441 aa |
- Manesia, J.K., Franch, M., Tabas-Madrid, D., Nogales-Cadenas, R., Vanwelden, T., Van Den Bosch, E., Xu, Z., Pascual-Montano, A., Khurana, S., Verfaillie, C. (2017) Distinct molecular signature of murine fetal liver and adult hematopoietic stem cells identifies novel regulators of hematopoietic stem cell function. Stem cells and development. 26(8):573-584
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Dhliwayo, N., Sarras, M.P., Luczkowski, E., Mason, S., Intine, R.V. (2014) Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation. Diabetes... 63(9):3069-76
- Ge, L., Zhang, R.P., Wan, F., Guo, D.Y., Wang, P., Xiang, L.X., and Shao, J.Z. (2014) TET2 Plays an Essential Role in Erythropoiesis by Regulating Lineage-Specific Genes via DNA Oxidative Demethylation in a Zebrafish Model. Molecular and cellular biology. 34(6):989-1002
- Lambert, M.J., Olsen, K.G., Cooper, C.D. (2014) Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish. Gene. 546(2):271-6
- Hirose, K., Shimoda, N., and Kikuchi, Y. (2013) Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin. Epigenetics. 8(9):899-906
- Powell, C., Grant, A.R., Cornblath, E., and Goldman, D. (2013) Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 110(49):19814-19819
- Powell, C., Elsaeidi, F., and Goldman, D. (2012) Injury-Dependent Muller Glia and Ganglion Cell Reprogramming during Tissue Regeneration Requires Apobec2a and Apobec2b. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(3):1096-1109
- Rai, K., Sarkar, S., Broadbent, T.J., Voas, M., Grossmann, K.F., Nadauld, L.D., Dehghanizadeh, S., Hagos, F.T., Li, Y., Toth, R.K., Chidester, S., Bahr, T.M., Johnson, W.E., Sklow, B., Burt, R., Cairns, B.R., and Jones, D.A. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell. 142(6):930-942
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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