Gene

ern1

ID

ZDB-GENE-050522-431

Name

endoplasmic reticulum to nucleus signaling 1

Symbol

ern1 Nomenclature History

Previous Names

sb:eu1005
zgc:109932

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Acts upstream of or within response to hypoxia. Is expressed in brain. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109932 (1 image)
eu1005 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ern1 Human Ortholog

No data available

Associated With ern1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR010513	KEN domain
Family	IPR045133	Serine/threonine-protein kinase/endoribonuclease IRE1/2-like
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR038357	KEN domain superfamily
Repeat	IPR018391	Pyrrolo-quinoline quinone beta-propeller repeat

Domain Details Per Protein

Protein	Additional Resources	Length	KEN domain	KEN domain superfamily	Protein kinase domain	Protein kinase-like domain superfamily	Pyrrolo-quinoline quinone beta-propeller repeat	Quinoprotein alcohol dehydrogenase-like superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinase/endoribonuclease IRE1/2-like	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q504E3	InterPro	292
UniProtKB:A0AB13A8S4	InterPro	1031

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ern1-201 (1) Ensembl	Ensembl	8,143 nt	Select Tool ZFIN BLAST
mRNA	ern1-202 (1) Ensembl	Ensembl	2,996 nt	Select Tool ZFIN BLAST
ncRNA	ern1-002 (1) Ensembl	Ensembl	344 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations