Gene
gemin4
- ID
- ZDB-GENE-050522-188
- Name
- gem (nuclear organelle) associated protein 4
- Symbol
- gemin4 Nomenclature History
- Previous Names
-
- im:7143815
- wu:fc41c09
- zgc:110169
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to be involved in spliceosomal snRNP assembly. Predicted to act upstream of or within rRNA processing. Predicted to be part of SMN complex. Is expressed in brain and midbrain hindbrain boundary neural rod. Human ortholog(s) of this gene implicated in alcohol dependence and neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities. Orthologous to human GEMIN4 (gem nuclear organelle associated protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7143815 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities | Alliance | Neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities | 617913 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR033265 | Gem-associated protein 4 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Gem-associated protein 4 |
|---|---|---|---|
| UniProtKB:Q503T2 | InterPro | 1057 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gemin4-201
(1)
|
Ensembl | 3,430 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-108P6 | ZFIN Curated Data | |
| Encodes | EST | fc41c09 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7143815 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110169 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173625 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192770 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001018144 (1) | 3446 nt | ||
| Genomic | GenBank:BX000431 (1) | 200161 nt | ||
| Polypeptide | UniProtKB:Q503T2 (1) | 1057 aa |
- Pei, W., Xu, L., Chen, Z., Slevin, C.C., Pettie, K.P., Wincovitch, S., NISC Comparative Sequencing Program, Burgess, S.M. (2020) A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation. NPJ Regenerative medicine. 5:6
- Cao, J., Tan, X. (2018) Comparative and evolutionary analysis of the 14-3-3 family genes in eleven fishes. Gene. 662:76-82
- Iwanami, N., Sikora, K., Richter, A.S., Mönnich, M., Guerri, L., Soza-Ried, C., Lawir, D.F., Mateos, F., Hess, I., O'Meara, C.P., Schorpp, M., Boehm, T. (2016) Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports. 17:2259-2270
- Hwang, J., Kim, H.S., Seok, J.W., Kim, J.D., Koun, S., Park, S.Y., Lee, J., Kim, H.S., Kim, H.S., Kim, K.S., Chang, K.T., Ryoo, Z.Y., Wang, S.M., Huh, T.L., and Lee, S. (2009) Transcriptome analysis of the zebrafish mind bomb mutant. Molecular genetics and genomics : MGG. 281(1):77-85
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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