tap1

ID

ZDB-GENE-050517-43

Name

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Symbol

tap1 Nomenclature History

Previous Names

abcb2 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable ABC-type peptide transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); bronchial disease (multiple); diffuse scleroderma; lung disease (multiple); and open-angle glaucoma. Orthologous to human TAP1 (transporter 1, ATP binding cassette subfamily B member).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Xu et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tap1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
MHC class I deficiency	Alliance	MHC class I deficiency 1	604571

Associated With tap1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017871	ABC transporter-like, conserved site
Domain	IPR003439	ABC transporter-like, ATP-binding domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR011527	ABC transporter type 1, transmembrane domain
Family	IPR039421	Type 1 protein exporter
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036640	ABC transporter type 1, transmembrane domain superfamily