Gene
dmrt1
- ID
- ZDB-GENE-050511-1
- Name
- doublesex and mab-3 related transcription factor 1
- Symbol
- dmrt1 Nomenclature History
- Previous Names
-
- zgc:136676
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including male germ cell proliferation; male gonad development; and male sex determination. Predicted to be active in nucleus. Is expressed in brain; liver; male organism; reproductive system; and spleen. Orthologous to human DMRT1 (doublesex and mab-3 related transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ihb399 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | CRISPR | |
ihb400 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | CRISPR | |
sa26559 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa31472 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
t32242 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
uc27 | Allele with one deletion | Unknown | Unknown | TALEN | |
uc67 | Allele with one deletion | Unknown | Unknown | TALEN | |
umo15 | Allele with one deletion | Unknown | Unknown | CRISPR | |
zm00173004Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-dmrt1 | (2) | |
CRISPR2-dmrt1 | (4) | |
CRISPR3-dmrt1 | Liang et al., 2023 | |
CRISPR4-dmrt1 | Liang et al., 2023 | |
CRISPR5-dmrt1 | Liang et al., 2023 | |
TALEN1-dmrt1 | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | DM DNA-binding domain | DM DNA-binding domain superfamily | DMRT family | Doublesex- and mab-3-related transcription factor 1-like |
---|---|---|---|---|---|---|
UniProtKB:Q71MM5 | InterPro | 267 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-146L2 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-31E5 | ZFIN Curated Data | |
Encodes | cDNA | MGC:136676 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_205628 (1) | 2668 nt | ||
Genomic | GenBank:BX255951 (1) | 171425 nt | ||
Polypeptide | UniProtKB:Q71MM5 (1) | 267 aa |
- Ge, S., Liu, Y., Huang, H., Yu, J., Li, X., Lin, Q., Huang, P., Mei, J. (2025) Chr23-miR-200s and Dmrt1 Control Sexually Dimorphic Trade-Off Between Reproduction and Growth in Zebrafish. International Journal of Molecular Sciences. 26:
- Shi, C., Zhang, Y., Lu, Y., Lou, Q., Shang, G., Peng, X., Dai, X., Jin, X., He, J., Zhai, G., Yin, Z. (2025) Insights into the role of Fsh signaling in ovarian differentiation of chorionic gonadotropin α ( cgα)-deficient zebrafish. Zoological research. 46:695708695-708
- Wang, Y., Xu, G., Li, H., Gao, J., Du, X., Jiang, W., Ji, G., Liu, Z. (2025) Zglp-1 is a novel essential transcriptional regulator for sex reversal in zebrafish. Marine life science & technology. 7:256270256-270
- Wu, K., Yue, Y., Zhou, L., Zhang, Z., Shan, H., He, H., Ge, W. (2025) Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis. Communications biology. 8:371371
- Li, C., Cai, R., Shi, W., Zhang, H., Liu, Z., Xie, F., Chen, Y., Hong, Q. (2024) Comparative transcriptome analysis of ovaries and testes reveals sex-biased genes and pathways in zebrafish. Gene. 901:148176
- Ren, Z., Ye, D., Su, N., Wang, C., He, L., Wang, H., He, M., Sun, Y. (2024) foxl2l is a germ cell-intrinsic gatekeeper of oogenesis in zebrafish. Zoological research. 45:111611301116-1130
- Ruan, Y., Li, X., Wang, X., Zhai, G., Lou, Q., Jin, X., He, J., Mei, J., Xiao, W., Gui, J., Yin, Z. (2024) New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesis. PLoS Genetics. 20:e1011170e1011170
- Liang, F., Dong, Z., Ye, J., Hu, W., Bhandari, R.K., Mai, K., Wang, X. (2023) In vivo DNA methylation editing in zebrafish. Epigenetics. 18:21923262192326
- Liao, X., Tao, B., Zhang, X., Chen, L., Chen, J., Song, Y., Hu, W. (2023) Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology. 576:112010
- Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918
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