Gene
dnah9l
- ID
- ZDB-GENE-050506-1
- Name
- dynein, axonemal, heavy polypeptide 9 like
- Symbol
- dnah9l Nomenclature History
- Previous Names
-
- dhc9 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Acts upstream of or within epithelial cilium movement involved in extracellular fluid movement. Located in extracellular region. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 7. Orthologous to human DNAH11 (dynein axonemal heavy chain 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la015802Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa9392 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa11038 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa20650 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa20651 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa20652 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa20653 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa20654 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa20655 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa30419 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 10 of 17
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Dynein heavy chain | Dynein heavy chain 3, AAA+ lid domain | Dynein heavy chain, AAA1 domain, small subdomain | Dynein heavy chain, AAA 5 extension domain | Dynein heavy chain AAA lid domain | Dynein heavy chain AAA lid domain superfamily | Dynein heavy chain, AAA module D4 | Dynein heavy chain, ATP-binding dynein motor region | Dynein heavy chain, coiled coil stalk | Dynein heavy chain, C-terminal domain | Dynein heavy chain, C-terminal domain, barrel region | Dynein heavy chain, domain 2, N-terminal | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Dynein heavy chain, linker | Dynein heavy chain, linker, subdomain 3 | Dynein heavy chain region D6 P-loop domain | Dynein heavy chain, tail | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0AB32TRA8 | InterPro | 4510 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
dnah9l-201
(1)
|
Ensembl | 11,802 nt | ||
mRNA |
dnah9l-202
(1)
|
Ensembl | 792 nt | ||
mRNA |
dnah9l-203
(1)
|
Ensembl | 772 nt | ||
mRNA |
dnah9l-204
(1)
|
Ensembl | 12,807 nt | ||
mRNA |
dnah9l-205
(1)
|
Ensembl | 12,660 nt |
1 - 5 of 5
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-34M19 | ZFIN Curated Data | |
Contained in | BAC | DKEY-240H6 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068221843 (1) | 15029 nt | ||
Genomic | GenBank:BX936397 (1) | 150369 nt | ||
Polypeptide | UniProtKB:A0AB32TRA8 (1) | 4510 aa |
No data available
- Yamaguchi, H., Oda, T., Kikkawa, M., Takeda, H. (2018) Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly. eLIFE. 7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Maddison, L.A., Lu, J., Victoroff, T., Scott, E., Baier, H., and Chen, W. (2009) A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Molecular genetics and genomics : MGG. 281(5):551-563
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Kramer-Zucker, A.G., Olale, F., Haycraft, C.J., Yoder, B.K., Schier, A.F., and Drummond, I.A. (2005) Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development (Cambridge, England). 132(8):1907-1921
1 - 6 of 6
Show