Gene
pglyrp5
- ID
- ZDB-GENE-050419-71
- Name
- peptidoglycan recognition protein 5
- Symbol
- pglyrp5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables N-acetylmuramoyl-L-alanine amidase activity. Acts upstream of or within defense response to bacterium. Is expressed in several structures, including cardiovascular system; gill; gut absorptive cell; liver; and pleuroperitoneal region. Orthologous to several human genes including PGLYRP1 (peptidoglycan recognition protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pglyrp5 | N/A | Li et al., 2007 |
| MO2-pglyrp5 | N/A | Li et al., 2025 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002502 | N-acetylmuramoyl-L-alanine amidase domain |
| Domain | IPR006619 | Peptidoglycan recognition protein family domain, metazoa/bacteria |
| Family | IPR015510 | Peptidoglycan recognition protein |
| Homologous_superfamily | IPR036505 | N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | N-acetylmuramoyl-L-alanine amidase domain | N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily | Peptidoglycan recognition protein | Peptidoglycan recognition protein family domain, metazoa/bacteria |
|---|---|---|---|---|---|---|
| UniProtKB:Q1W1Y2 | InterPro | 238 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pglyrp5-201
(1)
|
Ensembl | 1,209 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-202C21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-113G17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044321 (1) | 1219 nt | ||
| Genomic | GenBank:AL928979 | 193205 nt | ||
| Polypeptide | UniProtKB:Q1W1Y2 (1) | 238 aa |
No data available
- Li, X., Xiong, G., Luo, M., Mao, S., Zhang, R., Meng, Z., Li, J., Liao, X. (2025) Peptidoglycan recognition protein PGRP-5 is involved in immune defence and neuro-behavioral disorders in zebrafish embryos. PLoS One. 20:e0315714e0315714
- Bhandiwad, A.A., Chu, N.C., Semenova, S.A., Holmes, G.A., Burgess, H.A. (2022) A cerebellar-prepontine circuit for tonic immobility triggered by an inescapable threat. Science advances. 8:eabo0549
- Echeverry, F.A., Ijaz, S., Pereda, A.E. (2022) "Recording synaptic transmission from auditory mixed synapses on the Mauthner cells of developing zebrafish". eNeuro. 9(3):
- Horstick, E.J., Bayleyen, Y., Burgess, H.A. (2020) Molecular and cellular determinants of motor asymmetry in zebrafish. Nature communications. 11:1170
- Espenschied, S.T., Cronan, M.R., Matty, M.A., Mueller, O., Redinbo, M.R., Tobin, D.M., Rawls, J.F. (2019) Epithelial delamination is protective during pharmaceutical-induced enteropathy. Proceedings of the National Academy of Sciences of the United States of America. 116(34):16961-16970
- Murdoch, C.C., Espenschied, S.T., Matty, M.A., Mueller, O., Tobin, D.M., Rawls, J.F. (2019) Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization. PLoS pathogens. 15:e1007381
- Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2019) Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes. Developmental and comparative immunology. 101:103455
- Xie, Y., Tolmeijer, S., Oskam, J.M., Tonkens, T., Meijer, A.H., Schaaf, M.J.M. (2019) Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration. Disease models & mechanisms. 12(5):
- Zhang, F., Shan, S., Xu, X., Wang, Y., Zhang, Y., Yin, M., Yang, G. (2019) Molecular characterization and expression analysis of two peptidoglycan recognition proteins (CcPGRP5, CcPGRP6) in larvae ontogeny of common carp Cyprinus carpio L. and upon immune stimulation by bacteria. BMC veterinary research. 15:10
- Marsden, K.C., Jain, R.A., Wolman, M.A., Echeverry, F.A., Nelson, J.C., Hayer, K.E., Miltenberg, B., Pereda, A.E., Granato, M. (2018) A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold. Cell Reports. 23:878-887
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