Gene

eif2ak3

ID
ZDB-GENE-050414-2
Name
eukaryotic translation initiation factor 2-alpha kinase 3
Symbol
eif2ak3 Nomenclature History
Previous Names
  • PEK (1)
  • PERK (1)
  • zgc:152949
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Acts upstream of or within response to endoplasmic reticulum stress and response to hypoxia. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; liver; and male organism. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
it312Allele with one deletionExon 13FrameshiftCRISPR
la018397TgTransgenic insertionUnknownUnknownDNA
sa451Allele with one point mutationUnknownSplice SiteENU
sa4496Allele with one point mutationUnknownSplice SiteENU
sa42159Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-eif2ak3
    Zhang et al., 2021
    MO2-eif2ak3N/AMukaigasa et al., 2018
    MO1-eif2ak3N/A (3)
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    Human Disease
    Associated With eif2ak3 Human Ortholog
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Wolcott-Rallison syndrome Alliance Wolcott-Rallison syndrome 226980
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    Associated With eif2ak3 Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Family IPR050339 Cell Cycle and Stress Response Kinase
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    1 - 5 of 7 Show all
    Domain Details Per Protein
    Protein Additional Resources Length Cell Cycle and Stress Response Kinase Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Quinoprotein alcohol dehydrogenase-like superfamily Serine/threonine-protein kinase, active site WD40/YVTN repeat-like-containing domain superfamily
    UniProtKB:A0A8M2B3B8 InterPro 1099
    UniProtKB:B8JI14 InterPro 1099
    UniProtKB:A0AB32T749 InterPro 1099
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    Transcripts
    Genome Browsers
    Genome Build: GRCz11Chromosome: 13
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA eif2ak3-201 (1) Ensembl 1,675 nt
    mRNA eif2ak3-202 (1) Ensembl 3,970 nt
    ncRNA eif2ak3-003 (1) Ensembl 580 nt
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    Interactions and Pathways
    No data available
    Antibodies
    No data available
    Plasmids
    No data available
    Constructs
    No data available
    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inBACDKEY-12J14ZFIN Curated Data
    EncodescDNAMGC:152949ZFIN Curated Data
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanEIF2AK32
    Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Citations
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