Gene
ccnh
- ID
- ZDB-GENE-050320-13
- Name
- cyclin H
- Symbol
- ccnh Nomenclature History
- Previous Names
-
- zgc:114132
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to act upstream of or within DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be part of transcription factor TFIIK complex. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; liver; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human CCNH (cyclin H).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cyclin, C-terminal domain 2 | Cyclin/Cyclin-like subunit Ssn8 | CyclinH/Ccl1 | Cyclin-like domain | Cyclin-like superfamily | Cyclin, N-terminal |
---|---|---|---|---|---|---|---|---|
UniProtKB:A2BGI0 | InterPro | 319 | ||||||
UniProtKB:Q5BJA4 | InterPro | 319 | ||||||
UniProtKB:A0A8M9QDW3 | InterPro | 331 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-195M1 | ZFIN Curated Data | |
Encodes | cDNA | MGC:114132 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001013453 (1) | 1313 nt | ||
Genomic | GenBank:BX470189 (2) | 183070 nt | ||
Polypeptide | UniProtKB:A0A8M9QDW3 (1) | 331 aa |
- Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Kim, D.H., Kim, E.J., Kim, D.H., Park, S.W. (2020) Dact2 is involved in the regulation of epithelial-mesenchymal transition. Biochemical and Biophysical Research Communications. 524(1):190-197
- Lv, P., Ma, D., Gao, S., Zhang, Y., Bae, Y.K., Liang, G., Gao, S., Choi, J.H., Kim, C.H., Wang, L., Liu, F. (2020) Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells. Stem Cell Reports. 15(3):749-760
- Honjo, Y., Ichinohe, T. (2019) Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Cell biology international. 43(5):516-527
- Jung, I.H., Jung, D.E., Chung, Y.Y., Kim, K.S., Park, S.W. (2019) Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple Organs by Regulating Cell Cycle Progression. Neoplasia (New York, N.Y.). 21:1003-1014
- He, Y., Huang, C.X., Chen, N., Wu, M., Huang, Y., Liu, H., Tang, R., Wang, W.M., Wang, H.L. (2017) The zebrafish miR-125c is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations and embryogenesis.. Oncotarget. 8:73846-73859
- Liu, W., Wu, M., Huang, Z., Lian, J., Chen, J., Wang, T., Leung, A.Y., Liao, Y., Zhang, Z., Liu, Q., Yen, K., Lin, S., Zon, L.I., Wen, Z., Zhang, Y., Zhang, W. (2017) c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 31(1):222-233
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Silva, I.A., Cox, C.J., Leite, R.B., Cancela, M.L., Conceição, N. (2014) Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 172-173C:9-20
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