Gene

sod3a

ID

ZDB-GENE-050309-208

Name

superoxide dismutase 3, extracellular a

Symbol

sod3a Nomenclature History

Previous Names

im:7151832
zgc:165473

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Enables superoxide dismutase activity. Predicted to be involved in removal of superoxide radicals. Predicted to act upstream of or within superoxide metabolic process. Predicted to be located in Golgi apparatus and extracellular region. Is expressed in digestive system; eye; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7151832 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sod3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		[Superoxide dismutase, elevated extracellular]

Associated With sod3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018152	Superoxide dismutase, copper/zinc, binding site
Domain	IPR001424	Superoxide dismutase, copper/zinc binding domain
Family	IPR024134	Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
Homologous_superfamily	IPR036423	Superoxide dismutase-like, copper/zinc binding domain superfamily