Gene
apobec2a
- ID
- ZDB-GENE-050306-15
- Name
- apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a
- Symbol
- apobec2a Nomenclature History
- Previous Names
-
- apo2a (1)
- zgc:110762
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity and cytidine deaminase activity. Acts upstream of or within several processes, including cell dedifferentiation; heart looping; and sensory epithelium regeneration. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adaxial cell; axial hypoblast; cardiovascular system; musculature system; and retina. Orthologous to human APOBEC2 (apolipoprotein B mRNA editing enzyme catalytic subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6904559 (17 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-apobec2a | N/A | (5) |
| MO2-apobec2a | N/A | Etard et al., 2010 |
| MO3-apobec2a | N/A | Etard et al., 2010 |
| MO4-apobec2a | N/A | Vonica et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | APOBEC Cytidine Deaminase | Cytidine and deoxycytidylate deaminase domain | Cytidine deaminase-like |
|---|---|---|---|---|---|
| UniProtKB:Q5CZQ2 | InterPro | 249 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
apobec2a-201
(1)
|
Ensembl | 1,389 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:MYC-apobec2b-2A-FLAG-apobec2a,Cau.Tuba1:GFP) |
| 3 | (3) | ||
| Tg(hsp70l:MYC-apobec2b_180C>A-2A-FLAG-apobec2a_156C>A,Cau.:Tuba1:GFP) |
| 3 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-1687F11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6904559 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110762 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192285 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013314 (1) | 1376 nt | ||
| Genomic | GenBank:CU856139 (1) | 39899 nt | ||
| Polypeptide | UniProtKB:Q5CZQ2 (1) | 249 aa |
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Skjaerven, K.H., Jakt, L.M., Dahl, J.A., Espe, M., Aanes, H., Hamre, K., Fernandes, J.M. (2016) Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes. Scientific Reports. 6:34535
- Haug, M.F., Gesemann, M., Lazovic, V., Neuhauss, S.C. (2015) Eumetazoan Cryptochrome Phylogeny and Evolution. Genome biology and evolution. 7(2):601-19
- Dhliwayo, N., Sarras, M.P., Luczkowski, E., Mason, S., Intine, R.V. (2014) Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation. Diabetes. 63(9):3069-76
- Ge, L., Zhang, R.P., Wan, F., Guo, D.Y., Wang, P., Xiang, L.X., and Shao, J.Z. (2014) TET2 Plays an Essential Role in Erythropoiesis by Regulating Lineage-Specific Genes via DNA Oxidative Demethylation in a Zebrafish Model. Molecular and cellular biology. 34(6):989-1002
- Powell, C., Cornblath, E., Goldman, D. (2014) Zinc-binding Domain-dependent, Deaminase-independent Actions of Apolipoprotein B mRNA-editing Enzyme, Catalytic Polypeptide 2 (Apobec2), Mediate Its Effect on Zebrafish Retina Regeneration. The Journal of biological chemistry. 289(42):28924-41
- Shimoda, N., Hirose, K., Kaneto, R., Izawa, T., Yokoi, H., Hashimoto, N., Kikuchi, Y. (2014) No Evidence for AID/MBD4-Coupled DNA Demethylation in Zebrafish Embryos. PLoS One. 9:e114816
- Hirose, K., Shimoda, N., and Kikuchi, Y. (2013) Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin. Epigenetics. 8(9):899-906
- Powell, C., Grant, A.R., Cornblath, E., and Goldman, D. (2013) Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 110(49):19814-19819
- Powell, C., Elsaeidi, F., and Goldman, D. (2012) Injury-Dependent Muller Glia and Ganglion Cell Reprogramming during Tissue Regeneration Requires Apobec2a and Apobec2b. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(3):1096-1109
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